A review on the biology and properties of adipose tissue macrophages involved in adipose tissue physiological and pathophysiological processes

Obesity exhibits a correlation with metabolic inflammation and endoplasmic reticulum stress, promoting the progression of metabolic disease such as diabetes, hyperlipidemia, hyperuricemia and so on. Adipose tissue macrophages (ATMs) are central players in obesity-associated inflammation and metaboli...

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Bibliographic Details
Published in:Lipids in health and disease 2020-07, Vol.19 (1), p.164-164, Article 164
Main Authors: Li, Yunjia, Yun, Ke, Mu, Runqing
Format: Article
Language:English
Subjects:
Adipocytes
Adipocytes - metabolism
Adipocytes - pathology
Adipose tissue
Adipose Tissue - cytology
Adipose Tissue - metabolism
Adipose Tissue - physiopathology
Adipose tissue macrophages
Adipose tissues
Animals
Beige adipose tissue
Body fat
Brown adipose tissue
Cytokines
Development and progression
Diabetes mellitus
DNA methylation
Endoplasmic reticulum
Energy Metabolism
Enzymes
Genotype & phenotype
Glucose
Glucose metabolism
Glycolysis
Homeostasis
Humans
Hyperlipidemia
Hyperuricemia
Infections
Inflammation
Insulin resistance
Iron - metabolism
Lipid metabolism
Lipids
Macrophages
Macrophages - pathology
Macrophages - physiology
Metabolic disorders
Mitochondria
Nervous system
Obesity
Oxidative Phosphorylation
Phenotypes
Phosphorylation
Physiological aspects
Physiology
Polarization
Proteins
Review
Telmisartan
White adipose tissue
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Summary:Obesity exhibits a correlation with metabolic inflammation and endoplasmic reticulum stress, promoting the progression of metabolic disease such as diabetes, hyperlipidemia, hyperuricemia and so on. Adipose tissue macrophages (ATMs) are central players in obesity-associated inflammation and metabolic diseases. Macrophages are involved in lipid and energy metabolism and mitochondrial function in adipocytes. Macrophage polarization is accompanied by metabolic shifting between glycolysis and mitochondrial oxidative phosphorylation. Here, this review focuses on macrophage metabolism linked to functional phenotypes with an emphasis on macrophage polarization in adipose tissue physiological and pathophysiological processes. In particular, the interplay between ATMs and adipocytes in energy metabolism, glycolysis, OXPHOS, iron handing and even interactions with the nervous system have been reviewed. Overall, the understanding of protective and pathogenic roles of ATMs in adipose tissue can potentially provide strategies to prevent and treat obesity-related metabolic disorders.
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-020-01342-3