The Role of Metabolic Factors in Renal Cancers

• Published in: International journal of molecular sciences 2020-10, Vol.21 (19), p.7246
• Main Authors: Rysz, Jacek, Franczyk, Beata, Ławiński, Janusz, Olszewski, Robert, Gluba-Brzózka, Anna
• Format: Article
• Language: English
• Subjects: Adipocytes; Adipocytes - metabolism; Adipocytes - pathology; Body mass index; Body size; Carcinoma, Renal Cell - complications; Carcinoma, Renal Cell - metabolism; Carcinoma, Renal Cell - pathology; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Growth factors; Humans; Hypertension; Insulin; Insulin - metabolism; Insulin resistance; Insulin Resistance - genetics; Insulin-like growth factors; Kidney cancer; Kidney Neoplasms - complications; Kidney Neoplasms - metabolism; Kidney Neoplasms - pathology; Kinases; lipid disorders; Lipids; Obesity; Obesity - complications; Obesity - metabolism; Obesity - pathology; Physiological aspects; Prognosis; Renal cell carcinoma; Review; Risk; Risk Factors; Survival; Tumors
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms21197246

An increasing number of evidence indicates that metabolic factors may play an important role in the development and progression of certain types of cancers, including renal cell carcinoma (RCC). This tumour is the most common kidney cancer which accounts for approximately 3-5% of malignant tumours in adults. Numerous studies indicated that concomitant diseases, including diabetes mellitus (DM) and hypertension, as well as obesity, insulin resistance, and lipid disorders, may also influence the prognosis and cancer-specific overall survival. However, the results of studies concerning the impact of metabolic factors on RCC are controversial. It appears that obesity increases the risk of RCC development; however, it may be a favourable factor in terms of prognosis. Obesity is closely related to insulin resistance and the development of diabetes mellitus type 2 (DM2T) since the adipocytes in visceral tissue secrete substances responsible for insulin resistance, e.g., free fatty acids. Interactions between insulin and insulin-like growth factor (IGF) system appear to be of key importance in the development and progression of RCC; however, the exact role of insulin and IGFs in RCC pathophysiology remains elusive. Studies indicated that diabetes increased the risk of RCC, but it might not alter cancer-related survival. The risk associated with a lipid profile is most mysterious, as numerous studies provided conflicting results. Even though large studies unravelling pathomechanisms involved in cancer growth are required to finally establish the impact of metabolic factors on the development, progression, and prognosis of renal cancers, it seems that the monitoring of health conditions, such as diabetes, low body mass index (BMI), and lipid disorders is of high importance in clear-cell RCC.