Managing Severe Adverse Reactions to Biologicals in Severe Asthma

The use of biological agents in the treatment of various inflammatory and malignancy conditions has expanded rapidly. However, these agents can induce hypersensitivity reactions, posing significant clinical challenges. We conducted a retrospective study that included nine patients with severe asthma...

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Bibliographic Details
Published in:Biomedicines 2023-11, Vol.11 (12), p.3108
Main Authors: Balan, Radu-Gheorghe, Deleanu, Diana Mihaela, Pintea, Irena, Dobrican Baruta, Carmen Teodora, Man, Milena Adina, Bocsan, Ioana Corina, Muntean, Ioana Adriana
Format: Article
Language:English
Subjects:
Anaphylaxis
Asthma
biologic therapy
Biological products
desensitization
Drug dosages
Edema
Hypersensitivity
Immunoglobulin E
Inflammation
Ipilimumab
Malignancy
Medical research
Medicine, Experimental
Metabolism
Molecular weight
Monoclonal antibodies
Patients
Peptides
Proteins
Pulmonology
Quality of life
Side effects
Spirometry
Steroids
Urticaria
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Summary:The use of biological agents in the treatment of various inflammatory and malignancy conditions has expanded rapidly. However, these agents can induce hypersensitivity reactions, posing significant clinical challenges. We conducted a retrospective study that included nine patients with severe asthma who experienced hypersensitivity reactions to biological agents (omalizumab, benralizumab and dupilumab). Hypersensitivity reactions to biologicals in severe asthma were observed in 9 of 68 patients treated. In five cases, treatment was stopped or changed to another available biological, and for four patients administered under close surveillance, titrated provocation or desensitization was applied. Successful desensitization was achieved in three of the patients, allowing them to continue therapy without adverse reactions. Improvements in asthma control were observed post-desensitization, leading to the reduced need for systemic steroid treatments and an increase in quality of life. This study highlights the importance of recognizing hypersensitivity reactions to biologicals to have an appropriate approach for patients with severe asthma. As an effective approach for patients experiencing hypersensitivity reactions to biological agents, desensitization allows treatment continuation.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11123108