Magnetic targeting of paclitaxel-loaded poly(lactic- co -glycolic acid)-based nanoparticles for the treatment of glioblastoma

Glioblastoma (GBM) therapy is highly challenging, as the tumors are very aggressive due to infiltration into the surrounding normal brain tissue. Even a combination of the available therapeutic regimens may not debulk the tumor completely. GBM tumors are also known for recurrence, resulting in survi...

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Bibliographic Details
Published in:International journal of nanomedicine 2018-01, Vol.13, p.4509-4521
Main Authors: Ganipineni, Lakshmi Pallavi, Ucakar, Bernard, Joudiou, Nicolas, Bianco, John, Danhier, Pierre, Zhao, Mengnan, Bastiancich, Chiara, Gallez, Bernard, Danhier, Fabienne, Préat, Véronique
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Aqueous solutions
Biomedical materials
Blood-brain barrier
Blood-Brain Barrier - drug effects
Blood-Brain Barrier - pathology
Brain cancer
Brain research
Cancer
Cancer therapies
Cancer treatment
Cell division
Cell Line, Tumor
Chemotherapy
Contrast media
Diagnostic imaging
Drug delivery systems
EDTA
Endocytosis - drug effects
Female
Ferric oxide
Fluorescence
Fluorescence microscopy
Gadoterate meglumine
glioblastoma
Glioblastoma - drug therapy
Glioblastoma - pathology
Glioblastomas
Gliomas
Health aspects
Humans
Iron compounds
Lactic Acid - chemistry
Life Sciences
magnetic targeting
Magnetics
Mice, Nude
Microscopy
nanomedicine
Nanoparticles
Nanoparticles - chemistry
Nervous system
NMR
Nuclear magnetic resonance
Original Research
Paclitaxel - pharmacology
Paclitaxel - therapeutic use
Permeability
Pharmaceutical sciences
PLGA- based-nanoparticles
Polyglycolic Acid - chemistry
Polylactic Acid-Polyglycolic Acid Copolymer
Polyvinyl alcohol
Recurrence (Disease)
Surfactants
Survival Analysis
Tissue Distribution - drug effects
Toxicity
Tumors
Xenograft Model Antitumor Assays
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Description
Summary:Glioblastoma (GBM) therapy is highly challenging, as the tumors are very aggressive due to infiltration into the surrounding normal brain tissue. Even a combination of the available therapeutic regimens may not debulk the tumor completely. GBM tumors are also known for recurrence, resulting in survival rates averaging
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S165184