1-Arylsulfonyl-2-(pyridylmethylsulfinyl) benzimidazoles as new proton pump inhibitor prodrugs

New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2009-12, Vol.14 (12), p.5247-5280
Main Authors: Shin, Jai Moo, Sachs, George, Cho, Young-moon, Garst, Michael
Format: Article
Language:English
Subjects:
Acids
Benzimidazoles - chemistry
Benzimidazoles - pharmacology
Blood
Drug dosages
gastric acid secretion
Humans
Hydrolysis
Magnetic Resonance Spectroscopy
prodrug
Prodrugs - chemistry
Prodrugs - pharmacology
proton pump inhibitor
Proton Pump Inhibitors - chemistry
Proton Pump Inhibitors - pharmacology
Protons
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Description
Summary:New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules14125247