Patients with CKD Secondary to Glomerular Disorders have Lower Arterial Stiffness, as Compared to Hypertensive and Diabetic CKD

Background Chronic kidney disease (CKD) manifested as reduced GFR and/or albuminuria, has been known to accelerate arterial stiffness and early vascular aging (EVA). Diabetes, hypertension, and glomerular disorders are the leading causes of CKD and renal failure. The question which etiology contribu...

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Bibliographic Details
Published in:Artery research 2023-09, Vol.29 (3), p.73-78
Main Authors: Lencovsky, Ori, Angel-Korman, Avital, Glasswine, Erick, Tal-Ben Ishay, Rotem, Amital, Mor, Kukuy, Olga, Leiba, Adi
Format: Article
Language:English
Subjects:
Aortic stiffness
Arthritis
Biopsy
Blood pressure
Body mass index
CKD
Coronary vessels
Creatinine
Diabetes
Etiology
Glomerulonephritis
Hemoglobin
Hypertension
Inflammation
Kidney diseases
Lupus
Medicine
Medicine & Public Health
Pulse wave velocity
Research Article
Urine
Variables
Veins & arteries
Velocity
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Summary:Background Chronic kidney disease (CKD) manifested as reduced GFR and/or albuminuria, has been known to accelerate arterial stiffness and early vascular aging (EVA). Diabetes, hypertension, and glomerular disorders are the leading causes of CKD and renal failure. The question which etiology contributes more to this vascular phenomenon-hypertensive and diabetic CKD or CKD secondary to immune-mediated glomerulonephritis—remained unclear. Objective To compare pulse wave velocity (PWV), a marker of arterial stiffness, between CKD patients of different etiologies: hypertensive and diabetic nephrosclerosis. vs. CKD secondary to glomerular disorders. Methods Clinical data were collected on 56 patients followed at the Nephrology and Hypertension Institute in Samson Assuta Ashdod University Hospital. All patients had at least one visit at our Nephrology clinics prior to recruitment. All patients with a glomerular disorder had a clinical-pathological diagnosis based on a recent kidney biopsy. Pulse wave velocity (PWV) was measured using a validated Sphygmocor XCEL ® device. Univariate and multivariate analyses were performed to compare PWV between hypertensive/diabetic CKD and CKD secondary to glomerular disorders. Results PWV was significantly higher in the hypertensive/diabetic CKD group, compared to the CKD-GN group, with an average of. 12.2 m/s vs 8.3 m/s, respectively (p 
ISSN:1876-4401
1872-9312
1876-4401
DOI:10.1007/s44200-023-00034-4