Recent Insights into Roles of Hypoxia-Inducible Factors in Retinal Diseases

Hypoxia-inducible factors (HIFs) are transcriptional factors that function as strong regulators of oxygen homeostasis and cellular metabolisms. The maintenance of cellular oxygen levels is critical as either insufficient or excessive oxygen affects development and physiologic and pathologic conditio...

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Published in:International journal of molecular sciences 2024-09, Vol.25 (18), p.10140
Main Authors: Lee, Deokho, Tomita, Yohei, Miwa, Yukihiro, Kunimi, Hiromitsu, Nakai, Ayaka, Shoda, Chiho, Negishi, Kazuno, Kurihara, Toshihide
Format: Article
Language:English
Subjects:
Aging
Angiogenesis
Animals
Basic Helix-Loop-Helix Transcription Factors - metabolism
Blood gases
Development and progression
Diabetic Retinopathy - metabolism
Genes
Genetic aspects
Health aspects
Humans
Hypoxia
Hypoxia - metabolism
Hypoxia-Inducible Factor 1 - metabolism
ischemia
Kinases
Lasers
Lipids
Macular degeneration
Metabolism
Oxidative stress
Oxygen - metabolism
Photoreceptors
Physiological aspects
Proteins
Ratcliffe, Peter
Retina
Retina - metabolism
Retina - pathology
Retinal diseases
Retinal Diseases - metabolism
retinal ischemia
Review
Semenza, Gregg
Transcription factors
Vascular endothelial growth factor
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Summary:Hypoxia-inducible factors (HIFs) are transcriptional factors that function as strong regulators of oxygen homeostasis and cellular metabolisms. The maintenance of cellular oxygen levels is critical as either insufficient or excessive oxygen affects development and physiologic and pathologic conditions. In the eye, retinas have a high metabolic demand for oxygen. Retinal ischemia can cause visual impairment in various sight-threating disorders including age-related macular degeneration, diabetic retinopathy, and some types of glaucoma. Therefore, understanding the potential roles of HIFs in the retina is highly important for managing disease development and progression. This review focuses on the physiologic and pathologic roles of HIFs as regulators of oxygen homeostasis and cellular metabolism in the retina, drawing on recent evidence. Our summary will promote comprehensive approaches to targeting HIFs for therapeutic purposes in retinal diseases.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms251810140