A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating

When processing current sensory inputs, animals refer to related past experiences. Current information is then incorporated into the related neural network to update previously stored memories. However, the neuronal mechanism underlying the impact of memories of prior experiences on current learning...

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Bibliographic Details
Published in:Nature communications 2022-01, Vol.13 (1), p.41-41, Article 41
Main Authors: Suzuki, Akinobu, Kosugi, Sakurako, Murayama, Emi, Sasakawa, Eri, Ohkawa, Noriaki, Konno, Ayumu, Hirai, Hirokazu, Inokuchi, Kaoru
Format: Article
Language:English
Subjects:
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Amygdala
Amygdala - physiology
Animal memory
Animals
Brain - physiology
Circuits
Cortex (cingulate)
Cortex (parietal)
Cortex (somatosensory)
Gyrus Cinguli
Hippocampus - physiology
Humanities and Social Sciences
Information processing
Memory - physiology
Mice
multidisciplinary
Nerve Net - physiology
Neural networks
Neurons - physiology
Optogenetics - methods
Parietal Lobe - cytology
Parietal Lobe - physiology
Science
Science (multidisciplinary)
Sensory integration
Somatosensory Cortex - physiology
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Summary:When processing current sensory inputs, animals refer to related past experiences. Current information is then incorporated into the related neural network to update previously stored memories. However, the neuronal mechanism underlying the impact of memories of prior experiences on current learning is not well understood. Here, we found that a cellular ensemble in the posterior parietal cortex (PPC) that is activated during past experience mediates an interaction between past and current information to update memory through a PPC-anterior cingulate cortex circuit in mice. Moreover, optogenetic silencing of the PPC ensemble immediately after retrieval dissociated the interaction without affecting individual memories stored in the hippocampus and amygdala. Thus, a specific subpopulation of PPC cells represents past information and instructs downstream brain regions to update previous memories. Animals refer to related past experiences when processing sensory inputs. The authors show that a cellular ensemble in the posterior parietal cortex that is activated during past experience mediates an interaction between past and current information to update memory through a circuit including the anterior cingulate cortex.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-021-27763-x