Evaluation of the Ability of Nanostructured PEI-Coated Iron Oxide Nanoparticles to Incorporate Cisplatin during Synthesis

Nanoparticles (NPs) have a high potential for biological applications as they can be used as carriers for the controlled release of bioactive factors. Here we focused on poly(ethylenimine) (PEI)-coated iron oxide hybrid NPs obtained by hydrothermal synthesis in high pressure conditions and evaluated...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2017-10, Vol.7 (10), p.314
Main Authors: Tutuianu, Raluca, Popescu, Laura Madalina, Preda, Mihai Bogdan, Rosca, Ana-Maria, Piticescu, Roxana Mioara, Burlacu, Alexandrina
Format: Article
Language:English
Subjects:
Agglomeration
Anticancer properties
Biological activity
Cell culture
Chemical synthesis
Cisplatin
Controlled release
Drug delivery
Drug delivery systems
drug release
Entrapment
Fluorescence
Fluorescent indicators
High pressure
hydrothermal synthesis
Iron
Iron oxides
mesenchymal stem cells
Nanoparticles
poly(ethileneimine) iron oxide hybrid nanoparticles
tumor cells
Valinomycin
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Summary:Nanoparticles (NPs) have a high potential for biological applications as they can be used as carriers for the controlled release of bioactive factors. Here we focused on poly(ethylenimine) (PEI)-coated iron oxide hybrid NPs obtained by hydrothermal synthesis in high pressure conditions and evaluated their behavior in culture medium in the presence or absence of cells, as well as their ability to incorporate antitumor drug cisplatin. Our results showed that the hydrothermal conditions used for Fe-PEI NPs synthesis allowed the incorporation of cisplatin, which even increased its anti-tumor effects. Furthermore, the commonly occurring phenomenon of NPs aggregation in culture medium was exploited for further entrapment of other active molecules, such as the fluorescent dye DiI and valinomycin. The molecules bound to NPs during synthesis or during aggregation process were delivered inside various cells after in vitro and in vivo direct contact between cells and NPs and their biological activity was preserved, thus supporting the therapeutic value of Fe-PEI NPs as drug delivery tools.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano7100314