The Role of BANK1 in B Cell Signaling and Disease

The B cell scaffold protein with ankyrin repeats (BANK1) is expressed primarily in B cells and with multiple but discrete roles in B cell signaling, including B cell receptor signaling, CD40-related signaling, and Toll-like receptor (TLR) signaling. The gene for BANK1, located in chromosome 4, has b...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2021-05, Vol.10 (5), p.1184
Main Authors: Gómez Hernández, Gonzalo, Morell, María, Alarcón-Riquelme, Marta E.
Format: Article
Language:English
Subjects:
African Americans
Amino acids
Ankyrins
Autoimmune diseases
autoimmunity
B cell receptor
B cell scaffold with ankyrin repeats
B cells
CD40
CD40 antigen
Chromosome 4
Disease
Gene expression
genetic association
Genetic diversity
Insects
Lupus
Lymphatic system
Lymphocytes B
Medicin och hälsovetenskap
Mutation
Phenotypes
Phosphorylation
Population
Proteins
Review
Synergism
Systemic lupus erythematosus
TLR7 protein
TLR9 protein
Toll-like receptors
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Summary:The B cell scaffold protein with ankyrin repeats (BANK1) is expressed primarily in B cells and with multiple but discrete roles in B cell signaling, including B cell receptor signaling, CD40-related signaling, and Toll-like receptor (TLR) signaling. The gene for BANK1, located in chromosome 4, has been found to contain genetic variants that are associated with several autoimmune diseases and also other complex phenotypes, in particular, with systemic lupus erythematosus. Common genetic variants are associated with changes in BANK1 expression in B cells, while rare variants modify their capacity to bind efferent effectors during signaling. A BANK1-deficient model has shown the importance of BANK1 during TLR7 and TLR9 signaling and has confirmed its role in the disease. Still, much needs to be done to fully understand the function of BANK1, but the main conclusion is that it may be the link between different signaling functions within the B cells and they may act to synergize the various pathways within a cell. With this review, we hope to enhance the interest in this molecule.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells10051184