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Association between PM2.5 from a coal mine fire and FeNO concentration 7.5 years later

Background and aim There are few long-term studies of respiratory health effects of landscape fires, despite increasing frequency and intensity due to climate change. We investigated the association between exposure to coal mine fire PM.sub.2.5 and fractional exhaled nitric oxide (FeNO) concentratio...

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Published in:BMC pulmonary medicine 2024-06, Vol.24 (1), p.1-7
Main Authors: Kress, Sara, Lane, Tyler J, Brown, David, Smith, Catherine L, Gao, Caroline X, McCrabb, Thomas, Thomas, Mikayla, Borg, Brigitte M, Thompson, Bruce R, Abramson, Michael J
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container_title BMC pulmonary medicine
container_volume 24
creator Kress, Sara
Lane, Tyler J
Brown, David
Smith, Catherine L
Gao, Caroline X
McCrabb, Thomas
Thomas, Mikayla
Borg, Brigitte M
Thompson, Bruce R
Abramson, Michael J
description Background and aim There are few long-term studies of respiratory health effects of landscape fires, despite increasing frequency and intensity due to climate change. We investigated the association between exposure to coal mine fire PM.sub.2.5 and fractional exhaled nitric oxide (FeNO) concentration 7.5 years later. Methods Adult residents of Morwell, who were exposed to the 2014 Hazelwood mine fire over 6 weeks, and unexposed residents of Sale, participated in the Hazelwood Health Study Respiratory Stream in 2021, including measurements of FeNO concentration, a marker of eosinophilic airway inflammation. Individual exposure to coal mine fire PM.sub.2.5 was modelled and mapped to time-location diaries. The effect of exposure to PM.sub.2.5 on log-transformed FeNO in exhaled breath was investigated using multivariate linear regression models in the entire sample and stratified by potentially vulnerable subgroups. Results A total of 326 adults (mean age: 57 years) had FeNO measured. The median FeNO level (interquartile range [IQR]) was 17.5 [15.0] ppb, and individual daily exposure to coal mine fire PM.sub.2.5 was 7.2 [13.8] [micro]g/m.sup.3. We did not identify evidence of association between coal mine fire PM.sub.2.5 exposure and FeNO in the general adult sample, nor in various potentially vulnerable subgroups. The point estimates were consistently close to zero in the total sample and subgroups. Conclusion Despite previous short-term impacts on FeNO and respiratory health outcomes in the medium term, we found no evidence that PM.sub.2.5 from the Hazelwood coal mine fire was associated with any long-term impact on eosinophilic airway inflammation measured by FeNO levels. Keywords: Air pollution, Coal industry, Particulate matter, Respiratory, Smoke, Landscape fires
doi_str_mv 10.1186/s12890-024-03075-w
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We investigated the association between exposure to coal mine fire PM.sub.2.5 and fractional exhaled nitric oxide (FeNO) concentration 7.5 years later. Methods Adult residents of Morwell, who were exposed to the 2014 Hazelwood mine fire over 6 weeks, and unexposed residents of Sale, participated in the Hazelwood Health Study Respiratory Stream in 2021, including measurements of FeNO concentration, a marker of eosinophilic airway inflammation. Individual exposure to coal mine fire PM.sub.2.5 was modelled and mapped to time-location diaries. The effect of exposure to PM.sub.2.5 on log-transformed FeNO in exhaled breath was investigated using multivariate linear regression models in the entire sample and stratified by potentially vulnerable subgroups. Results A total of 326 adults (mean age: 57 years) had FeNO measured. The median FeNO level (interquartile range [IQR]) was 17.5 [15.0] ppb, and individual daily exposure to coal mine fire PM.sub.2.5 was 7.2 [13.8] [micro]g/m.sup.3. We did not identify evidence of association between coal mine fire PM.sub.2.5 exposure and FeNO in the general adult sample, nor in various potentially vulnerable subgroups. The point estimates were consistently close to zero in the total sample and subgroups. Conclusion Despite previous short-term impacts on FeNO and respiratory health outcomes in the medium term, we found no evidence that PM.sub.2.5 from the Hazelwood coal mine fire was associated with any long-term impact on eosinophilic airway inflammation measured by FeNO levels. 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This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11157905/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3066885060?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,38516,43895,44590,53791,53793</link.rule.ids></links><search><creatorcontrib>Kress, Sara</creatorcontrib><creatorcontrib>Lane, Tyler J</creatorcontrib><creatorcontrib>Brown, David</creatorcontrib><creatorcontrib>Smith, Catherine L</creatorcontrib><creatorcontrib>Gao, Caroline X</creatorcontrib><creatorcontrib>McCrabb, Thomas</creatorcontrib><creatorcontrib>Thomas, Mikayla</creatorcontrib><creatorcontrib>Borg, Brigitte M</creatorcontrib><creatorcontrib>Thompson, Bruce R</creatorcontrib><creatorcontrib>Abramson, Michael J</creatorcontrib><title>Association between PM2.5 from a coal mine fire and FeNO concentration 7.5 years later</title><title>BMC pulmonary medicine</title><description>Background and aim There are few long-term studies of respiratory health effects of landscape fires, despite increasing frequency and intensity due to climate change. We investigated the association between exposure to coal mine fire PM.sub.2.5 and fractional exhaled nitric oxide (FeNO) concentration 7.5 years later. Methods Adult residents of Morwell, who were exposed to the 2014 Hazelwood mine fire over 6 weeks, and unexposed residents of Sale, participated in the Hazelwood Health Study Respiratory Stream in 2021, including measurements of FeNO concentration, a marker of eosinophilic airway inflammation. Individual exposure to coal mine fire PM.sub.2.5 was modelled and mapped to time-location diaries. The effect of exposure to PM.sub.2.5 on log-transformed FeNO in exhaled breath was investigated using multivariate linear regression models in the entire sample and stratified by potentially vulnerable subgroups. Results A total of 326 adults (mean age: 57 years) had FeNO measured. The median FeNO level (interquartile range [IQR]) was 17.5 [15.0] ppb, and individual daily exposure to coal mine fire PM.sub.2.5 was 7.2 [13.8] [micro]g/m.sup.3. We did not identify evidence of association between coal mine fire PM.sub.2.5 exposure and FeNO in the general adult sample, nor in various potentially vulnerable subgroups. The point estimates were consistently close to zero in the total sample and subgroups. Conclusion Despite previous short-term impacts on FeNO and respiratory health outcomes in the medium term, we found no evidence that PM.sub.2.5 from the Hazelwood coal mine fire was associated with any long-term impact on eosinophilic airway inflammation measured by FeNO levels. 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We investigated the association between exposure to coal mine fire PM.sub.2.5 and fractional exhaled nitric oxide (FeNO) concentration 7.5 years later. Methods Adult residents of Morwell, who were exposed to the 2014 Hazelwood mine fire over 6 weeks, and unexposed residents of Sale, participated in the Hazelwood Health Study Respiratory Stream in 2021, including measurements of FeNO concentration, a marker of eosinophilic airway inflammation. Individual exposure to coal mine fire PM.sub.2.5 was modelled and mapped to time-location diaries. The effect of exposure to PM.sub.2.5 on log-transformed FeNO in exhaled breath was investigated using multivariate linear regression models in the entire sample and stratified by potentially vulnerable subgroups. Results A total of 326 adults (mean age: 57 years) had FeNO measured. The median FeNO level (interquartile range [IQR]) was 17.5 [15.0] ppb, and individual daily exposure to coal mine fire PM.sub.2.5 was 7.2 [13.8] [micro]g/m.sup.3. We did not identify evidence of association between coal mine fire PM.sub.2.5 exposure and FeNO in the general adult sample, nor in various potentially vulnerable subgroups. The point estimates were consistently close to zero in the total sample and subgroups. Conclusion Despite previous short-term impacts on FeNO and respiratory health outcomes in the medium term, we found no evidence that PM.sub.2.5 from the Hazelwood coal mine fire was associated with any long-term impact on eosinophilic airway inflammation measured by FeNO levels. Keywords: Air pollution, Coal industry, Particulate matter, Respiratory, Smoke, Landscape fires</abstract><cop>London</cop><pub>BioMed Central Ltd</pub><pmid>38844929</pmid><doi>10.1186/s12890-024-03075-w</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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source Publicly Available Content Database; PubMed Central; Coronavirus Research Database
subjects Air pollution
Asthma
Body mass index
Chronic obstructive pulmonary disease
Climate change
Coal
Coal industry
Coal mining
Composition
Environmental aspects
Health aspects
Inflammation
Landscape fires
Leukocytes (eosinophilic)
Nitric oxide
Outdoor air quality
Particles
Particulate matter
Regression analysis
Respiratory
Respiratory tract diseases
Sensitivity analysis
Smoke
Spirometry
Toxicity
title Association between PM2.5 from a coal mine fire and FeNO concentration 7.5 years later
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