Performance measurement of intraoperative systolic arterial pressure to predict in-hospital mortality in adult liver transplantation

Profound hypotension during liver transplantation is aggressively treated with vasopressors thus frequently unrevealed in a retrospective study. The relationship between concealed intraoperative hypotension and in-hospital mortality after liver transplantation was evaluated using performance measure...

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Bibliographic Details
Published in:Scientific reports 2017-08, Vol.7 (1), p.7030-9, Article 7030
Main Authors: Lee, Hyung-Chul, Ryu, Ho-Geol, Jung, Chul-Woo
Format: Article
Language:English
Subjects:
692/308/409
692/499
692/699/1503/1607
Aged
Arterial Pressure
Blood Pressure
Female
Hospital Mortality
Humanities and Social Sciences
Humans
Hypotension
Intraoperative Period
Liver
Liver transplantation
Liver Transplantation - adverse effects
Liver transplants
Male
Middle Aged
Mortality
multidisciplinary
Performance evaluation
Postoperative Complications - mortality
Prediction models
Prognosis
Retrospective Studies
ROC Curve
SAP protein
Science
Science (multidisciplinary)
Sensitivity and Specificity
Transplantation
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Summary:Profound hypotension during liver transplantation is aggressively treated with vasopressors thus frequently unrevealed in a retrospective study. The relationship between concealed intraoperative hypotension and in-hospital mortality after liver transplantation was evaluated using performance measurement (PM) of systolic arterial pressure (SAP). Median performance error (MDPE), median absolute performance error (MDAPE), and wobble of SAP were calculated using preoperative SAP as the reference value, and prereperfusion and postreperfusion SAPs as measured values. Univariable and multivariable logistic regression analyses were performed using 6 PM parameters and 36 traditional SAP-derived parameters to predict in-hospital mortality. In-hospital mortality was 3.9% (22/569 cases). Prereperfusion MDAPE and postreperfusion wobble were the only significant SAP-derived predictors of in-hospital mortality. The area under receiver operating characteristic curve of prediction model was 0.769 (95% confidence interval 0.732–0.803, P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-07664-0