High prevalence of carbapenem-resistant Enterobacterales (CRE) in human samples from Nigeria: A systematic review and meta-analysis

The rise in Carbapenem-resistant Enterobacterales (CRE) is perturbing. To curb the menace of CRE, a comprehensive understanding of its prevalence and epidemiology is crucial. As varying reports abound, the true prevalence of CRE in Nigeria remains unknown. Here, we conducted a systematic review and...

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Published in:Heliyon 2024-08, Vol.10 (15), p.e34926, Article e34926
Main Authors: Irekeola, Ahmad Adebayo, Shueb, Rafidah Hanim, Engku Abd Rahman, Engku Nur Syafirah, Afolabi, Hafeez Abiola, Wada, Yusuf, Elmi, Abdirahman Hussein, Hakami, Muath Abdu, Alghzwani, Sfeeah Mofareah, Elnoubi, Osman AE, Alshehri, Ahmad A.
Format: Article
Language:English
Subjects:
Carbapenem
computer software
doripenem
Enterobacterales
epidemiology
ertapenem
Escherichia coli
humans
imipenem
Klebsiella pneumoniae
meropenem
meta-analysis
Morganella
Nigeria
Resistance
systematic review
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Summary:The rise in Carbapenem-resistant Enterobacterales (CRE) is perturbing. To curb the menace of CRE, a comprehensive understanding of its prevalence and epidemiology is crucial. As varying reports abound, the true prevalence of CRE in Nigeria remains unknown. Here, we conducted a systematic review and meta-analysis following standard guidelines to assess the situation of CRE in Nigeria. We searched electronic databases including Pubmed, ScienceDirect, Scopus, Web of Science, and Google Scholar for articles providing information on CRE in Nigeria. The data gathered were analyzed using OpenMeta Analyst and Comprehensive Meta-Analysis software. The random-effect model was employed to calculate pooled resistance to carbapenem antibiotics. From 321 retrieved records, 57 were finally included. The studies were predominantly from the South-West region (n = 19). Escherichia coli and Klebsiella pneumoniae were the most frequently tested Enterobacterales among the included studies. The pooled prevalence estimate for imipenem resistance among CRE was 11.2 % (95 % CI: 7.9–15.7). Meropenem resistance had an estimate of 13.5 % (95 % CI: 9.1–19.6), whereas ertapenem and doripenem were estimated at 17.0 % (95 % CI: 9.9–27.7) and 37.9 % (95 % CI: 15.0–67.8), respectively. High heterogeneity (I2>85 %, p 
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e34926