Alcohol Consumption and Its Influence on the Clinical Picture of Puumala Hantavirus Infection

Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. Characteristic clinical findings include acute kidney injury (AKI), thrombocytopenia, and capillary leakage. Smoking increases the risk of severe AKI, but it is not known whether alcohol consumption predisposes patients to a mor...

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Bibliographic Details
Published in:Viruses 2022-02, Vol.14 (3), p.500
Main Authors: Tervo, Laura, Outinen, Tuula K, Mäkelä, Satu, Mustalahti, Jenna, Huhtala, Heini, Pörsti, Ilkka, Syrjänen, Jaana, Mustonen, Jukka T, Niemelä, Onni
Format: Article
Language:English
Subjects:
Abdomen
Acute Disease
Acute Kidney Injury
Alanine
Alanine transaminase
alcohol drinking
Alcohol Drinking - adverse effects
Alcohol use
Bacterial infections
Biomarkers
Blood platelets
Clinical outcomes
Convalescence
Creatinine
Drinking behavior
Enzymes
ethanol
Fever
Hantavirus
Hantavirus Infections - complications
Hematuria
Hemorrhage
Hemorrhagic fever with renal syndrome
Hemorrhagic Fever with Renal Syndrome - diagnosis
Humans
Infections
Laboratories
Length of stay
Liver
liver enzymes
Orthohantavirus
Pain
Pancreatitis
Pancreatitis - complications
Patients
Pneumonia
Population studies
Puumala hantavirus
Puumala virus
Smoking
Thrombocytopenia
Transferrin
Urine
Viral infections
γ-Glutamyltransferase
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Summary:Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. Characteristic clinical findings include acute kidney injury (AKI), thrombocytopenia, and capillary leakage. Smoking increases the risk of severe AKI, but it is not known whether alcohol consumption predisposes patients to a more severe infection. Liver and pancreatic enzymes, as well as biomarkers of alcohol consumption (gamma-glutamyl transferase, GGT; carbohydrate-deficient transferrin, CDT; GGT-CDT combination; and ethyl glucuronide, EtG), were measured from 66 patients with acute PUUV infection during hospitalization and at the convalescence phase. Alcohol consumption was present in 41% of the study population, 15% showing signs of heavy drinking. Alcohol use did not affect the severity of PUUV induced AKI nor the overall clinical picture of the infection. Liver enzyme levels (GGT or alanine aminotransferase, ALT) were elevated in 64% of the patients, but the levels did not associate with the markers reflecting the severity of the disease. Serum amylase activities at the convalescent stage were higher than those at the acute phase (p < 0.001). No cases with acute pancreatitis were found. In conclusion, our findings indicate that alcohol consumption does not seem to affect the clinical course of an acute PUUV infection.
ISSN:1999-4915
1999-4915
DOI:10.3390/v14030500