A Review of the Role of Natural Products as Treatment Approaches for Xerostomia

Xerostomia, commonly known as dry mouth, is a widespread oral health malfunction characterized by decreased salivary flow. This condition results in discomfort, impaired speech and mastication, dysphagia, heightened susceptibility to oral infections, and ultimately, a diminished oral health-related...

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Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2023-08, Vol.16 (8), p.1136
Main Authors: Kontogiannopoulos, Konstantinos N, Kapourani, Afroditi, Gkougkourelas, Ioannis, Anagnostaki, Maria-Emmanouela, Tsalikis, Lazaros, Assimopoulou, Andreana N, Barmpalexis, Panagiotis
Format: Article
Language:English
Subjects:
artificial saliva
Care and treatment
dry mouth
Exocrine glands
Health aspects
Membrane separation
Microorganisms
Natural products
Patient outcomes
Pharmaceutical sciences
R&D
Research & development
Review
salivary substitutes
Tropical diseases
Xerostomia
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Summary:Xerostomia, commonly known as dry mouth, is a widespread oral health malfunction characterized by decreased salivary flow. This condition results in discomfort, impaired speech and mastication, dysphagia, heightened susceptibility to oral infections, and ultimately, a diminished oral health-related quality of life. The etiology of xerostomia is multifaceted, with primary causes encompassing the use of xerostomic medications, radiation therapy to the head and neck, and systemic diseases such as Sjögren’s syndrome. Consequently, there is a growing interest in devising management strategies to address this oral health issue, which presents significant challenges due to the intricate nature of saliva. Historically, natural products have served medicinal purposes, and in contemporary pharmaceutical research and development, they continue to play a crucial role, including the treatment of xerostomia. In this context, the present review aims to provide an overview of the current state of knowledge regarding natural compounds and extracts for xerostomia treatment, paving the way for developing novel therapeutic strategies for this common oral health issue.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph16081136