Abnormal Whole Brain Functional Connectivity Pattern Homogeneity and Couplings in Migraine Without Aura

Previous studies have reported abnormal amplitude of low-frequency fluctuation and regional homogeneity in patients with migraine without aura using resting-state functional magnetic resonance imaging. However, how whole brain functional connectivity pattern homogeneity and its corresponding functio...

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Bibliographic Details
Published in:Frontiers in human neuroscience 2020-12, Vol.14, p.619839-619839
Main Authors: Zhang, Yingxia, Chen, Hong, Zeng, Min, He, Junwei, Qi, Guiqiang, Zhang, Shaojin, Liu, Rongbo
Format: Article
Language:English
Subjects:
Age
Brain mapping
Cortex (cingulate)
Demographics
FCHo
functional connectivity
Functional magnetic resonance imaging
Headache
Hospitals
Human Neuroscience
Magnetic resonance imaging
Migraine
migraine without aura
Neural networks
Neuroimaging
Pain
Precentral gyrus
Prefrontal cortex
resting-state
Thalamus
Time series
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Summary:Previous studies have reported abnormal amplitude of low-frequency fluctuation and regional homogeneity in patients with migraine without aura using resting-state functional magnetic resonance imaging. However, how whole brain functional connectivity pattern homogeneity and its corresponding functional connectivity changes in patients with migraine without aura is unknown. In the current study, we employed a recently developed whole brain functional connectivity homogeneity (FcHo) method to identify the voxel-wise changes of functional connectivity patterns in 21 patients with migraine without aura and 21 gender and age matched healthy controls. Moreover, resting-state functional connectivity analysis was used to reveal the changes of corresponding functional connectivities. FcHo analyses identified significantly decreased FcHo values in the posterior cingulate cortex (PCC), thalamus (THA), and left anterior insula (AI) in patients with migraine without aura compared to healthy controls. Functional connectivity analyses further found decreased functional connectivities between PCC and medial prefrontal cortex (MPFC), between AI and anterior cingulate cortex, and between THA and left precentral gyrus (PCG). The functional connectivities between THA and PCG were negatively correlated with pain intensity. Our findings indicated that whole brain FcHo and connectivity abnormalities of these regions may be associated with functional impairments in pain processing in patients with migraine without aura.
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2020.619839