Clinical characteristics of coronavirus disease 2019 (COVID-19) in patients out of Wuhan from China: a case control study

• Published in: BMC infectious diseases 2021-02, Vol.21 (1), p.207-207, Article 207
• Main Authors: Zhang, Hua, Du, Feng, Cao, Xiao-Jun, Feng, Xia-Long, Zhang, He-Ping, Wu, Zheng-Xia, Wang, Bao-Feng, Zhang, Hong-Juan, Liu, Rui, Yang, Jian-Jun, Ning, Bo, Chen, Kai, Huang, Zhen-Peng
• Format: Article
• Language: English
• Subjects: 2019-nCoV; Adult; Age; Aged; Amyloid; Anorexia; C-reactive protein; C-Reactive Protein - analysis; Case-Control Studies; China; China - epidemiology; Clinical characteristics; Computed tomography; Coronaviridae; Coronaviruses; Cough; COVID-19; COVID-19 - blood; COVID-19 - complications; COVID-19 - epidemiology; Demographic aspects; Diabetes; Disease transmission; Dyspnea; Epidemics; Epidemiology; Fatalities; Female; Fever; Humans; Hypertension; Infections; Infectious diseases; Male; Medical imaging; Mental disorders; Middle Aged; Middle East respiratory syndrome; Morphology; Neutrophils; Oxygenation; Oxyhemoglobin; Patients; Respiratory diseases; SARS-CoV-2; Saturation; Serum Amyloid A Protein - analysis; Severe acute respiratory syndrome coronavirus 2; Signs and symptoms; Statistical analysis; Statistics; Tomography, X-Ray Computed; Viral diseases; Wuhan
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-021-05897-z

A large-scale global outbreak of coronavirus disease-19 (COVID-19) out of Wuhan, from China, occurred in January 2020. To examine the clinical characteristics of COVID-19 in infected patients out of Wuhan, from China. Thirteen patients were confirmed to be infected with novel coronavirus-2019 (2019-nCoV) between January 27 and February 8, 2020, in Baoji city, Shannxi, northwestern China. Epidemiological and clinical information, and computed to morphology imaging data from all COVID-19 patients were collected; cases were divided into two groups according to the severity of infection (mild or severe). Nine (9/13) COVID-19 patients exhibited mild disease severity, and defined as second-generation human-to-human transmission cases. Most patients (11/13) had a history of travel to or from Wuhan. There were no differences in sex and age between the mild and severe cases (all P > 0.05). A moderate degree of fever (11/13), cough (13/13), and fatigue (8/13) were common symptoms; however, there was no statistical difference between mild and severe cases in this regard (all P > 0.05). Oxyhemoglobin saturation and oxygenation index decreased, and C-reactive protein (CRP) and serum amyloid A (SAA) levels were elevated in all patients with COVID-19 infection, with statistically significant differences between those with severe disease and mild infection (all P