Pulmonary Hypertension Is Associated With Systemic Arterial Hypertension Among Patients With Normal Left Ventricular Diastolic Function

• Published in: Journal of the American Heart Association 2021-12, Vol.10 (24), p.e023603-e023603
• Main Authors: Itelman, Edward, Segel, Michael J, Kuperstein, Rafael, Feinberg, Micha, Segev, Amit, Segal, Gad, Maor, Elad, Grossman, Ehud
• Format: Article
• Language: English
• Subjects: Adult; Aged; Diastole - physiology; diastolic dysfunction; Female; Humans; Hypertension - epidemiology; Hypertension, Pulmonary - epidemiology; Male; Middle Aged; Original Research; pulmonary hypertension; systemic arterial hypertension; Ventricular Function, Left - physiology
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.121.023603

Background The association of pulmonary and systemic arterial hypertension is believed to be mediated through hypertensive left heart disease. The purpose of the current study was to investigate whether pulmonary hypertension (PHT) is associated with systemic arterial hypertension among patients with apparently normal left ventricular diastolic function. Methods and Results Consecutive patients who had echocardiographic evaluation between 2007 and 2019 were enrolled. Patients with disease states that are known to be associated with PHT, including diastolic dysfunction, were excluded from the analysis. Estimated right ventricular systolic pressure was extracted for all patients from the echocardiographic reports. PHT was defined as estimated right ventricular systolic pressure >40 mm Hg. Multivariate logistic regression models were applied. Final study population included 25 916 patients with a median age of 59 (interquartile range, 44-69) years, of whom 12 501 (48%) were men and 13 265 (51%) had systemic arterial hypertension. Compared with normotensive patients, hypertensive patients were 3.2 times more likely to have PHT (95% CI, 2.91-3.53;