The Application of Brain Organoids in Assessing Neural Toxicity

The human brain is a complicated and precisely organized organ. Exogenous chemicals, such as pollutants, drugs, and industrial chemicals, may affect the biological processes of the brain or its function and eventually lead to neurological diseases. Animal models may not fully recapitulate the human...

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Bibliographic Details
Published in:Frontiers in molecular neuroscience 2022-02, Vol.15, p.799397
Main Authors: Fan, Pan, Wang, YuanHao, Xu, Min, Han, Xiao, Liu, Yan
Format: Article
Language:English
Subjects:
Animal models
assembloid
Blood vessels
Brain
brain organoid
brain organoid transplantation
Circulatory system
Nervous system
neural toxicity
Neurological diseases
Neuroscience
Neurotoxicity
Nutrients
Organoids
Pollutants
Stem cells
Toxicants
vascularization
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Summary:The human brain is a complicated and precisely organized organ. Exogenous chemicals, such as pollutants, drugs, and industrial chemicals, may affect the biological processes of the brain or its function and eventually lead to neurological diseases. Animal models may not fully recapitulate the human brain for testing neural toxicity. Brain organoids with self-assembled three-dimensional (3D) structures provide opportunities to generate relevant tests or predictions of human neurotoxicity. In this study, we reviewed recent advances in brain organoid techniques and their application in assessing neural toxicants. We hope this review provides new insights for further progress in brain organoid application in the screening studies of neural toxicants.
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2022.799397