Disseminated bacille Calmette―Guérin disease in HIV-infected South African infants

To determine the population-based incidence of disseminated bacille Calmette-Guérin (BCG) disease in HIV-infected infants (aged

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Published in:Bulletin of the World Health Organization 2009-07, Vol.87 (7), p.505-511
Main Authors: HESSELING, A. C, JOHNSON, L. F, BEYERS, N, GODFREY-FAUSSETT, P, JASPAN, H, COTTON, M. F, WHITELAW, A, SCHAAF, H. S, FINE, Pem, ELEY, B. S, MARAIS, B. J, NUTTALL, J
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Age
AIDS
Animals
Bacterial diseases
BCG Vaccine - adverse effects
Biological and medical sciences
Case reports
Cattle
Children & youth
Comorbidity
Confidence intervals
Disease prevention
Disease transmission
Epidemiology
General aspects
HIV
HIV Seropositivity
Human bacterial diseases
Human immunodeficiency virus
Humans
Immunization
Infant
Infections
Infectious Disease Transmission, Vertical
Infectious diseases
Laboratories
Lymphatic system
Medical sciences
Medical tests
Miscellaneous
Mycobacterium bovis
Pediatrics
Population
Population Surveillance
Prospective Studies
Public health. Hygiene
Public health. Hygiene-occupational medicine
South Africa - epidemiology
Surveillance
Tuberculosis
Tuberculosis and atypical mycobacterial infections
Tuberculosis, Bovine - epidemiology
Tuberculosis, Bovine - transmission
Womens health
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cited_by cdi_FETCH-LOGICAL-c570t-ff3ee91b5262ded54aa2b94bed4b64f27140cf35408160c0624dca454c4a5d153
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container_end_page 511
container_issue 7
container_start_page 505
container_title Bulletin of the World Health Organization
container_volume 87
creator HESSELING, A. C
JOHNSON, L. F
BEYERS, N
GODFREY-FAUSSETT, P
JASPAN, H
COTTON, M. F
WHITELAW, A
SCHAAF, H. S
FINE, Pem
ELEY, B. S
MARAIS, B. J
NUTTALL, J
description To determine the population-based incidence of disseminated bacille Calmette-Guérin (BCG) disease in HIV-infected infants (aged
doi_str_mv 10.2471/BLT.08.055657
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C ; JOHNSON, L. F ; BEYERS, N ; GODFREY-FAUSSETT, P ; JASPAN, H ; COTTON, M. F ; WHITELAW, A ; SCHAAF, H. S ; FINE, Pem ; ELEY, B. S ; MARAIS, B. J ; NUTTALL, J</creator><creatorcontrib>HESSELING, A. C ; JOHNSON, L. F ; BEYERS, N ; GODFREY-FAUSSETT, P ; JASPAN, H ; COTTON, M. F ; WHITELAW, A ; SCHAAF, H. S ; FINE, Pem ; ELEY, B. S ; MARAIS, B. J ; NUTTALL, J</creatorcontrib><description>To determine the population-based incidence of disseminated bacille Calmette-Guérin (BCG) disease in HIV-infected infants (aged &lt;or= 1 year) in a setting with a high burden of tuberculosis and HIV infection coupled with a well-functioning programme for the prevention of HIV infection in infants. The numerator, or number of new cases of disseminated BCG disease, was derived from multicentre surveillance data collected prospectively on infants with a confirmed HIV infection during 2004-2006. The denominator, or total number of HIV-infected infants who were BCG-vaccinated, was derived from population-based estimates of the number of live infants and from reported maternal HIV infection prevalence, vertical HIV transmission rates and BCG vaccination rates. The estimated incidences of disseminated BCG disease per 100 000 BCG-vaccinated, HIV-infected infants were as follows: 778 (95% confidence interval, CI: 361-1319) in 2004 (vertical HIV transmission rate: 10.4%); 1300 (95% CI: 587-2290) in 2005 (transmission rate: 6.1%); and 1013 (95% CI: 377-1895) in 2006 (transmission rate: 5.4%). The pooled incidence over the study period was 992 (95% CI: 567-1495) per 100 000. Multicentre surveillance data showed that the risk of disseminated BCG disease in HIV-infected infants is considerably higher than previously estimated, although likely to be under-estimated. There is an urgent need for data on the risk-benefit ratio of BCG vaccination in HIV-infected infants to inform decision-making in settings where HIV infection and tuberculosis burdens are high. Safe and effective tuberculosis prevention strategies are needed for HIV-infected infants.</description><identifier>ISSN: 0042-9686</identifier><identifier>EISSN: 1564-0604</identifier><identifier>DOI: 10.2471/BLT.08.055657</identifier><identifier>PMID: 19649364</identifier><identifier>CODEN: BWHOA6</identifier><language>eng</language><publisher>Genève: Organisation mondiale de la santé</publisher><subject>Acquired immune deficiency syndrome ; Age ; AIDS ; Animals ; Bacterial diseases ; BCG Vaccine - adverse effects ; Biological and medical sciences ; Case reports ; Cattle ; Children &amp; youth ; Comorbidity ; Confidence intervals ; Disease prevention ; Disease transmission ; Epidemiology ; General aspects ; HIV ; HIV Seropositivity ; Human bacterial diseases ; Human immunodeficiency virus ; Humans ; Immunization ; Infant ; Infections ; Infectious Disease Transmission, Vertical ; Infectious diseases ; Laboratories ; Lymphatic system ; Medical sciences ; Medical tests ; Miscellaneous ; Mycobacterium bovis ; Pediatrics ; Population ; Population Surveillance ; Prospective Studies ; Public health. 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C</creatorcontrib><creatorcontrib>JOHNSON, L. F</creatorcontrib><creatorcontrib>BEYERS, N</creatorcontrib><creatorcontrib>GODFREY-FAUSSETT, P</creatorcontrib><creatorcontrib>JASPAN, H</creatorcontrib><creatorcontrib>COTTON, M. F</creatorcontrib><creatorcontrib>WHITELAW, A</creatorcontrib><creatorcontrib>SCHAAF, H. S</creatorcontrib><creatorcontrib>FINE, Pem</creatorcontrib><creatorcontrib>ELEY, B. S</creatorcontrib><creatorcontrib>MARAIS, B. J</creatorcontrib><creatorcontrib>NUTTALL, J</creatorcontrib><title>Disseminated bacille Calmette―Guérin disease in HIV-infected South African infants</title><title>Bulletin of the World Health Organization</title><addtitle>Bull World Health Organ</addtitle><description>To determine the population-based incidence of disseminated bacille Calmette-Guérin (BCG) disease in HIV-infected infants (aged &lt;or= 1 year) in a setting with a high burden of tuberculosis and HIV infection coupled with a well-functioning programme for the prevention of HIV infection in infants. The numerator, or number of new cases of disseminated BCG disease, was derived from multicentre surveillance data collected prospectively on infants with a confirmed HIV infection during 2004-2006. The denominator, or total number of HIV-infected infants who were BCG-vaccinated, was derived from population-based estimates of the number of live infants and from reported maternal HIV infection prevalence, vertical HIV transmission rates and BCG vaccination rates. The estimated incidences of disseminated BCG disease per 100 000 BCG-vaccinated, HIV-infected infants were as follows: 778 (95% confidence interval, CI: 361-1319) in 2004 (vertical HIV transmission rate: 10.4%); 1300 (95% CI: 587-2290) in 2005 (transmission rate: 6.1%); and 1013 (95% CI: 377-1895) in 2006 (transmission rate: 5.4%). The pooled incidence over the study period was 992 (95% CI: 567-1495) per 100 000. Multicentre surveillance data showed that the risk of disseminated BCG disease in HIV-infected infants is considerably higher than previously estimated, although likely to be under-estimated. There is an urgent need for data on the risk-benefit ratio of BCG vaccination in HIV-infected infants to inform decision-making in settings where HIV infection and tuberculosis burdens are high. 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C</au><au>JOHNSON, L. F</au><au>BEYERS, N</au><au>GODFREY-FAUSSETT, P</au><au>JASPAN, H</au><au>COTTON, M. F</au><au>WHITELAW, A</au><au>SCHAAF, H. S</au><au>FINE, Pem</au><au>ELEY, B. S</au><au>MARAIS, B. J</au><au>NUTTALL, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disseminated bacille Calmette―Guérin disease in HIV-infected South African infants</atitle><jtitle>Bulletin of the World Health Organization</jtitle><addtitle>Bull World Health Organ</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>87</volume><issue>7</issue><spage>505</spage><epage>511</epage><pages>505-511</pages><issn>0042-9686</issn><eissn>1564-0604</eissn><coden>BWHOA6</coden><abstract>To determine the population-based incidence of disseminated bacille Calmette-Guérin (BCG) disease in HIV-infected infants (aged &lt;or= 1 year) in a setting with a high burden of tuberculosis and HIV infection coupled with a well-functioning programme for the prevention of HIV infection in infants. The numerator, or number of new cases of disseminated BCG disease, was derived from multicentre surveillance data collected prospectively on infants with a confirmed HIV infection during 2004-2006. The denominator, or total number of HIV-infected infants who were BCG-vaccinated, was derived from population-based estimates of the number of live infants and from reported maternal HIV infection prevalence, vertical HIV transmission rates and BCG vaccination rates. The estimated incidences of disseminated BCG disease per 100 000 BCG-vaccinated, HIV-infected infants were as follows: 778 (95% confidence interval, CI: 361-1319) in 2004 (vertical HIV transmission rate: 10.4%); 1300 (95% CI: 587-2290) in 2005 (transmission rate: 6.1%); and 1013 (95% CI: 377-1895) in 2006 (transmission rate: 5.4%). The pooled incidence over the study period was 992 (95% CI: 567-1495) per 100 000. Multicentre surveillance data showed that the risk of disseminated BCG disease in HIV-infected infants is considerably higher than previously estimated, although likely to be under-estimated. There is an urgent need for data on the risk-benefit ratio of BCG vaccination in HIV-infected infants to inform decision-making in settings where HIV infection and tuberculosis burdens are high. Safe and effective tuberculosis prevention strategies are needed for HIV-infected infants.</abstract><cop>Genève</cop><pub>Organisation mondiale de la santé</pub><pmid>19649364</pmid><doi>10.2471/BLT.08.055657</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 0042-9686
ispartof Bulletin of the World Health Organization, 2009-07, Vol.87 (7), p.505-511
issn 0042-9686
1564-0604
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_c23494ee312440c59a8f1c007f50fcb7
source International Bibliography of the Social Sciences (IBSS); ABI/INFORM Global (ProQuest); Politics Collection; Social Science Premium Collection (Proquest) (PQ_SDU_P3); PAIS Index; PubMed Central
subjects Acquired immune deficiency syndrome
Age
AIDS
Animals
Bacterial diseases
BCG Vaccine - adverse effects
Biological and medical sciences
Case reports
Cattle
Children & youth
Comorbidity
Confidence intervals
Disease prevention
Disease transmission
Epidemiology
General aspects
HIV
HIV Seropositivity
Human bacterial diseases
Human immunodeficiency virus
Humans
Immunization
Infant
Infections
Infectious Disease Transmission, Vertical
Infectious diseases
Laboratories
Lymphatic system
Medical sciences
Medical tests
Miscellaneous
Mycobacterium bovis
Pediatrics
Population
Population Surveillance
Prospective Studies
Public health. Hygiene
Public health. Hygiene-occupational medicine
South Africa - epidemiology
Surveillance
Tuberculosis
Tuberculosis and atypical mycobacterial infections
Tuberculosis, Bovine - epidemiology
Tuberculosis, Bovine - transmission
Womens health
title Disseminated bacille Calmette―Guérin disease in HIV-infected South African infants
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