Compound C inhibits the replication of feline coronavirus

Feline Coronavirus (FCoV) is a viral pathogen of cats and a highly contagious virus. Cats in a cattery can be infected by up to 100%, and even household cats are infected by 20–60%. Some strains of FCoV are known to induce a fatal disease in cats named Feline Infectious Peritonitis (FIP). However, n...

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Bibliographic Details
Published in:Heliyon 2024-03, Vol.10 (6), p.e27641-e27641, Article e27641
Main Authors: Park, Yeonjeong, Kim, Chansoo, Park, Yea-In, Lee, Siyun, So, Jaeyeon, Park, Rackhyun, Park, Junsoo
Format: Article
Language:English
Subjects:
AMPK
Compound C
Feline coronavirus
Feline enteric coronavirus
Feline infectious peritonitis
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Summary:Feline Coronavirus (FCoV) is a viral pathogen of cats and a highly contagious virus. Cats in a cattery can be infected by up to 100%, and even household cats are infected by 20–60%. Some strains of FCoV are known to induce a fatal disease in cats named Feline Infectious Peritonitis (FIP). However, no effective treatments are available. We demonstrated that compound C (dorsomorphin) can potentially inhibit feline coronavirus replication. Compound C treatment decreased the FCoV-induced plaque formation and cytopathic effect in FCoV-infected cells. Compound C treatment also significantly reduced the amount of viral RNA and viral protein in the cells in a dose-dependent manner. Our findings suggest that compound C is potentially useful for feline coronavirus-related diseases. •Compound C, an AMPK inhibitor, inhibits feline coronavirus replication.•Compound C reduces the expression of feline coronavirus protein and RNA.•Compound C alleviates FECV-induced cytopathic effect.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e27641