High-mobility group box 1 expression in mandibular bone cells of experimental periodontitis

Background: High-mobility group box 1 (HMGB1) was suggested to be associated with the pathogenesis of chronic periodontitis which characterized by alveolar bone loss. HMGB1 was defined as a bone-active cytokine, but the rule of HMGB1 in bone loss of chronic periodontitis is still understood. Aim: Th...

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Bibliographic Details
Published in:Contemporary clinical dentistry 2019-07, Vol.10 (3), p.525-530
Main Authors: Da'at Arina, Yuliana, Rubianto, Mohamad, Ferdiansyah, F, Sudiana, I, Rahayu, Retno, Notobroto, Hari
Format: Article
Language:English
Subjects:
Alveolar bone
Analysis
Bone loss
Bone marrow
Chromosomal proteins
chronic periodontitis
Cytokines
Cytoplasm
EDTA
Ethylenediaminetetraacetic acid
Gum disease
high-mobility group box 1
HMGB1 protein
Immunohistochemistry
Inflammation
Mandible
mandibular bone cell
Mobility
Original
Osteoblasts
osteoblasts/osteoclasts
Osteoclasts
Pathogenesis
Periodontitis
Tumor necrosis factor-TNF
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Summary:Background: High-mobility group box 1 (HMGB1) was suggested to be associated with the pathogenesis of chronic periodontitis which characterized by alveolar bone loss. HMGB1 was defined as a bone-active cytokine, but the rule of HMGB1 in bone loss of chronic periodontitis is still understood. Aim: The aim of this study is to investigate the expression of HMGB1 on osteoblasts and osteoclasts in the mandible of chronic periodontitis. Methods: This experimental study was conducted to rats injected by Porphyromonas gingivalis into the buccal and lingual subgingival area at a concentration of 2 × 109 CFU/mL three times a week with 2-day apart for 2, 3, 4, and 6 weeks as chronic periodontitis group and injected by normal saline as control group. Analysis of variance was used to examine the differences between groups followed by least significant difference post hoc test with the level of significance was
ISSN:0976-237X
0976-2361
DOI:10.4103/ccd.ccd_907_18