High-mobility group box 1 expression in mandibular bone cells of experimental periodontitis

Background: High-mobility group box 1 (HMGB1) was suggested to be associated with the pathogenesis of chronic periodontitis which characterized by alveolar bone loss. HMGB1 was defined as a bone-active cytokine, but the rule of HMGB1 in bone loss of chronic periodontitis is still understood. Aim: Th...

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Published in:Contemporary clinical dentistry 2019-07, Vol.10 (3), p.525-530
Main Authors: Da'at Arina, Yuliana, Rubianto, Mohamad, Ferdiansyah, F, Sudiana, I, Rahayu, Retno, Notobroto, Hari
Format: Article
Language:English
Subjects:
Alveolar bone
Analysis
Bone loss
Bone marrow
Chromosomal proteins
chronic periodontitis
Cytokines
Cytoplasm
EDTA
Ethylenediaminetetraacetic acid
Gum disease
high-mobility group box 1
HMGB1 protein
Immunohistochemistry
Inflammation
Mandible
mandibular bone cell
Mobility
Original
Osteoblasts
osteoblasts/osteoclasts
Osteoclasts
Pathogenesis
Periodontitis
Tumor necrosis factor-TNF
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container_title Contemporary clinical dentistry
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creator Da'at Arina, Yuliana
Rubianto, Mohamad
Ferdiansyah, F
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Rahayu, Retno
Notobroto, Hari
description Background: High-mobility group box 1 (HMGB1) was suggested to be associated with the pathogenesis of chronic periodontitis which characterized by alveolar bone loss. HMGB1 was defined as a bone-active cytokine, but the rule of HMGB1 in bone loss of chronic periodontitis is still understood. Aim: The aim of this study is to investigate the expression of HMGB1 on osteoblasts and osteoclasts in the mandible of chronic periodontitis. Methods: This experimental study was conducted to rats injected by Porphyromonas gingivalis into the buccal and lingual subgingival area at a concentration of 2 × 109 CFU/mL three times a week with 2-day apart for 2, 3, 4, and 6 weeks as chronic periodontitis group and injected by normal saline as control group. Analysis of variance was used to examine the differences between groups followed by least significant difference post hoc test with the level of significance was
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HMGB1 was defined as a bone-active cytokine, but the rule of HMGB1 in bone loss of chronic periodontitis is still understood. Aim: The aim of this study is to investigate the expression of HMGB1 on osteoblasts and osteoclasts in the mandible of chronic periodontitis. Methods: This experimental study was conducted to rats injected by Porphyromonas gingivalis into the buccal and lingual subgingival area at a concentration of 2 × 109 CFU/mL three times a week with 2-day apart for 2, 3, 4, and 6 weeks as chronic periodontitis group and injected by normal saline as control group. Analysis of variance was used to examine the differences between groups followed by least significant difference post hoc test with the level of significance was &lt;0.05. Results: The HMGB1 expression was found in both osteoclasts and osteoblasts of mandibular bone by immunohistochemistry analysis. There was a difference of HMGB1 expression on osteoblasts and osteoclasts of chronic periodontitis. HMGB1 expression was found increased significantly in mandibular osteoblasts of chronic periodontitis, whereas the HMGB1 expression in mandibular osteoclast is higher in 2 and 3 weeks, but it was lower in 4 and 6 weeks. Conclusions: This study indicated a potential role for HMGB1 in bone loss of chronic periodontitis. HMGB1 on mandibular osteoclasts and osteoblasts may play different rules in the onset and progression of chronic periodontitis.</description><identifier>ISSN: 0976-237X</identifier><identifier>EISSN: 0976-2361</identifier><identifier>DOI: 10.4103/ccd.ccd_907_18</identifier><identifier>PMID: 32308332</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. 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This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). 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HMGB1 was defined as a bone-active cytokine, but the rule of HMGB1 in bone loss of chronic periodontitis is still understood. Aim: The aim of this study is to investigate the expression of HMGB1 on osteoblasts and osteoclasts in the mandible of chronic periodontitis. Methods: This experimental study was conducted to rats injected by Porphyromonas gingivalis into the buccal and lingual subgingival area at a concentration of 2 × 109 CFU/mL three times a week with 2-day apart for 2, 3, 4, and 6 weeks as chronic periodontitis group and injected by normal saline as control group. Analysis of variance was used to examine the differences between groups followed by least significant difference post hoc test with the level of significance was &lt;0.05. Results: The HMGB1 expression was found in both osteoclasts and osteoblasts of mandibular bone by immunohistochemistry analysis. There was a difference of HMGB1 expression on osteoblasts and osteoclasts of chronic periodontitis. 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HMGB1 was defined as a bone-active cytokine, but the rule of HMGB1 in bone loss of chronic periodontitis is still understood. Aim: The aim of this study is to investigate the expression of HMGB1 on osteoblasts and osteoclasts in the mandible of chronic periodontitis. Methods: This experimental study was conducted to rats injected by Porphyromonas gingivalis into the buccal and lingual subgingival area at a concentration of 2 × 109 CFU/mL three times a week with 2-day apart for 2, 3, 4, and 6 weeks as chronic periodontitis group and injected by normal saline as control group. Analysis of variance was used to examine the differences between groups followed by least significant difference post hoc test with the level of significance was &lt;0.05. Results: The HMGB1 expression was found in both osteoclasts and osteoblasts of mandibular bone by immunohistochemistry analysis. There was a difference of HMGB1 expression on osteoblasts and osteoclasts of chronic periodontitis. HMGB1 expression was found increased significantly in mandibular osteoblasts of chronic periodontitis, whereas the HMGB1 expression in mandibular osteoclast is higher in 2 and 3 weeks, but it was lower in 4 and 6 weeks. Conclusions: This study indicated a potential role for HMGB1 in bone loss of chronic periodontitis. HMGB1 on mandibular osteoclasts and osteoblasts may play different rules in the onset and progression of chronic periodontitis.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>32308332</pmid><doi>10.4103/ccd.ccd_907_18</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Alveolar bone
Analysis
Bone loss
Bone marrow
Chromosomal proteins
chronic periodontitis
Cytokines
Cytoplasm
EDTA
Ethylenediaminetetraacetic acid
Gum disease
high-mobility group box 1
HMGB1 protein
Immunohistochemistry
Inflammation
Mandible
mandibular bone cell
Mobility
Original
Osteoblasts
osteoblasts/osteoclasts
Osteoclasts
Pathogenesis
Periodontitis
Tumor necrosis factor-TNF
title High-mobility group box 1 expression in mandibular bone cells of experimental periodontitis
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