Core-Shell Magnetic Gold Nanoparticles for Magnetic Field-Enhanced Radio-Photothermal Therapy in Cervical Cancer

The combination of radiotherapy (RT) and photothermal therapy (PTT) has been considered an attractive strategy in cervical cancer treatment. However, it remains a challenge to simultaneously enhance the radio-sensitivity of tumor tissue, develop tumor tissue-focused radiation therapies and combine d...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2017-05, Vol.7 (5), p.111
Main Authors: Hu, Rui, Zheng, Minxue, Wu, Jinchang, Li, Cheng, Shen, Danqing, Yang, Dian, Li, Li, Ge, Mingfeng, Chang, Zhimin, Dong, Wenfei
Format: Article
Language:English
Subjects:
Anticancer properties
Biocompatibility
Cancer
Cancer therapies
Cervical cancer
Cervix
Gold
I.R. radiation
In vitro methods and tests
Internalization
Iron oxides
Irradiation
magnetic field
Magnetic fields
magnetic gold nanoparticles
Magnetic resonance
Nanoparticles
Near infrared radiation
Photothermal conversion
Radiation therapy
Radio
radio-photothermal therapy
Sensitivity enhancement
Surface plasmon resonance
synergetic
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Summary:The combination of radiotherapy (RT) and photothermal therapy (PTT) has been considered an attractive strategy in cervical cancer treatment. However, it remains a challenge to simultaneously enhance the radio-sensitivity of tumor tissue, develop tumor tissue-focused radiation therapies and combine dual therapeutic modalities. In this study, core-shell type magnetic gold (Fe₃O₄@Au) nanoparticles are exploited to achieve the synergistic efficacy of radio-photothermal therapy in cervical cancer. Fe₃O₄@Au nanoparticles (NPs) with uniform morphology exhibited superior surface plasmon resonance properties, excellent superparamagnetic properties, good biocompatibility and high photothermal conversion efficiency. For the in vitro tests, a low concentration of Fe₃O₄@Au NPs after a short period of near-infrared irradiation lead to the time-dependent death of cervical cancer cells. Further, the combination of RT and PTT induced synergistic anti-cancer effects in vitro. More importantly, an external magnetic field could significantly enhance the synergistic efficacy of Fe₃O₄@Au NPs by improving their internalization. Hence, the reported Fe₃O₄@Au NPs have the potential to be good nanoagents with excellent magnetic targeting ability for cervical cancer radio-photothermal treatment.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano7050111