Reduced volume of the left cerebellar lobule VIIb and its increased connectivity within the cerebellum predict more general psychopathology one year later via worse cognitive flexibility in children

Predicting the risk for general psychopathology (the p factor) requires the examination of multiple factors ranging from brain to cognitive skills. While an increasing number of findings have reported the roles of the cerebral cortex and executive functions, it is much less clear whether and how the...

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Bibliographic Details
Published in:Developmental cognitive neuroscience 2023-10, Vol.63, p.101296, Article 101296
Main Authors: Zhao, Gai, Zhang, Haibo, Ma, Leilei, Wang, Yanpei, Chen, Rui, Liu, Ningyu, Men, Weiwei, Tan, Shuping, Gao, Jia-Hong, Qin, Shaozheng, He, Yong, Dong, Qi, Tao, Sha
Format: Article
Language:English
Subjects:
Brain
Cerebellum - pathology
Cerebral Cortex
Child
Cognition
Cognitive flexibility
Connectivity
Humans
Left cerebellar lobule VIIb
Magnetic Resonance Imaging
Mental Disorders - pathology
Original Research
P factor
School-age children
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Summary:Predicting the risk for general psychopathology (the p factor) requires the examination of multiple factors ranging from brain to cognitive skills. While an increasing number of findings have reported the roles of the cerebral cortex and executive functions, it is much less clear whether and how the cerebellum and cognitive flexibility (a core component of executive function) may be associated with the risk for general psychopathology. Based on the data from more than 400 children aged 6–12 in the Children School Functions and Brain Development (CBD) Project, this study examined whether the left cerebellar lobule VIIb and its connectivity within the cerebellum may prospectively predict the risk for general psychopathology one year later and whether cognitive flexibility may mediate such predictions in school-age children. The reduced gray matter volume in the left cerebellar lobule VIIb and the increased connectivity of this region to the left cerebellar lobule VI prospectively predicted the risk for general psychopathology and was partially mediated by worse cognitive flexibility. Deficits in cognitive flexibility may play an important role in linking cerebellar structure and function to the risk for general psychopathology.
ISSN:1878-9293
1878-9307
1878-9307
DOI:10.1016/j.dcn.2023.101296