The Potential Role of Salivary NT-proBNP in Heart Failure

Background: Serum natriuretic peptides (NPs) have an established role in heart failure (HF) diagnosis. Saliva NT-proBNP that may be easily acquired has been studied little. Methods: Ninety-nine subjects were enrolled; thirty-six obese or hypertensive with dyspnoea but no echocardiographic HF finding...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2023-08, Vol.13 (9), p.1818
Main Authors: Rammos, Aidonis, Bechlioulis, Aris, Kalogeras, Petros, Watson, Chris J, Salvo, Pietro, Lomonaco, Tommaso, Kardakari, Olga, Tripoliti, Evanthia E, Goletsis, Yorgos, Fotiadis, Dimitris I, Katsouras, Christos S, Michalis, Lampros K, Naka, Katerina K
Format: Article
Language:English
Subjects:
acute heart failure
Biomarkers
Brain natriuretic peptide
Cardiology
Cardiovascular disease
chronic heart failure
Congestive heart failure
Coronary vessels
Diagnosis
Dyspnea
Echocardiography
EKG
Electrocardiography
Health aspects
Heart failure
heart failure diagnosis
Hospitals
Hypertension
Inflammation
Kidney diseases
Measurement
Methods
Obesity
Oral cancer
Patients
Peptides
Respiration
Risk factors
Saliva
saliva NT-proBNP
salivary biomarkers
Salivary diagnostics
Serum levels
Severe acute respiratory syndrome coronavirus 2
Ultrasonic imaging
Variables
Vegetarianism
Vein & artery diseases
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Summary:Background: Serum natriuretic peptides (NPs) have an established role in heart failure (HF) diagnosis. Saliva NT-proBNP that may be easily acquired has been studied little. Methods: Ninety-nine subjects were enrolled; thirty-six obese or hypertensive with dyspnoea but no echocardiographic HF findings or raised NPs served as controls, thirteen chronic HF (CHF) patients and fifty patients with acute decompensated HF (ADHF) requiring hospital admission. Electrocardiogram, echocardiogram, 6 min walking distance (6MWD), blood and saliva samples, were acquired in all participants. Results: Serum NT-proBNP ranged from 60–9000 pg/mL and saliva NT-proBNP from 0.64–93.32 pg/mL. Serum NT-proBNP was significantly higher in ADHF compared to CHF (p = 0.007) and in CHF compared to controls (p < 0.05). There was no significant difference in saliva values between ADHF and CHF, or between CHF and controls. Saliva and serum levels were positively associated only in ADHF patients (R = 0.352, p = 0.012). Serum NT-proBNP was positively associated with NYHA class (R = 0.506, p < 0.001) and inversely with 6MWD (R = −0.401, p = 0.004) in ADHF. Saliva NT-proBNP only correlated with age in ADHF patients. Conclusions: In the current study, saliva NT-proBNP correlated with serum values in ADHF patients, but could not discriminate between HF and other causes of dyspnoea. Further research is needed to explore the value of saliva NT-proBNP.
ISSN:2075-1729
2075-1729
DOI:10.3390/life13091818