DNA Methylation in Stroke. Update of Latest Advances

Epigenetic modifications are hereditable and modifiable factors that do not alter the DNA sequence. These epigenetic factors include DNA methylation, acetylation of histones and non-coding RNAs. Epigenetic factors have mainly been associated with cancer but also with other diseases and conditions su...

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Bibliographic Details
Published in:Computational and structural biotechnology journal 2018-01, Vol.16, p.1-5
Main Authors: Krupinski, Jerzy, Carrera, Caty, Muiño, Elena, Torres, Nuria, Al-Baradie, Raid, Cullell, Natalia, Fernandez-Cadenas, Israel
Format: Article
Language:English
Subjects:
Epigenetics
EWAs
Genetics
GWAs
Short Survey
Stroke
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Summary:Epigenetic modifications are hereditable and modifiable factors that do not alter the DNA sequence. These epigenetic factors include DNA methylation, acetylation of histones and non-coding RNAs. Epigenetic factors have mainly been associated with cancer but also with other diseases and conditions such as diabetes or obesity. In addition, epigenetic modifications could play an important role in cardiovascular diseases, including stroke. We review the latest advances in stroke epigenetics, focusing on DNA methylation studies and the future perspectives in this field.
ISSN:2001-0370
2001-0370
DOI:10.1016/j.csbj.2017.12.001