Herbal Mixture of Carthamus tinctorius L. Seed and Taraxacum coreanum Attenuates Amyloid Beta-Induced Cognitive Dysfunction In Vivo

Deposition of amyloid-beta (Aβ) in the aging brain has been often observed and is thought to be a pathological feature of Alzheimer's disease. The use of natural products for disease prevention and treatment is gaining attention worldwide. L. seed and have been used as traditional medicines in...

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Bibliographic Details
Published in:Foods 2022-01, Vol.11 (2), p.142
Main Authors: He, Meitong, Kim, Jihyun, Park, Chanhum, Cho, Eunju
Format: Article
Language:English
Subjects:
Aging
Aging (natural)
Alzheimer's disease
Amyloidogenesis
Animal cognition
Carthamus tinctorius
Carthamus tinctorius L. seed
Cognition
Cognitive ability
cognitive dysfunction
Experiments
Food science
Functional foods & nutraceuticals
In vivo methods and tests
Inflammation
Learning
Memory
Natural products
Neurodegenerative diseases
Object recognition
Oxidative stress
Pattern recognition
Peptides
Proteins
Secretase
Seeds
Taraxacum
Taraxacum coreanum
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Summary:Deposition of amyloid-beta (Aβ) in the aging brain has been often observed and is thought to be a pathological feature of Alzheimer's disease. The use of natural products for disease prevention and treatment is gaining attention worldwide. L. seed and have been used as traditional medicines in Asian countries, where they have been reported to exert anti-inflammatory and anti-oxidative effects. It has been demonstrated that the combination of L. seed and has an effect on cognitive enhancement, indicating a ratio of 5:5 synergistically enhancing learning and memory abilities in comparison with a single treatment. Here, we aimed to investigate the protective effect of L. seed and mixture (CT) at different concentrations on cognition in Aβ -infused mice. CT-administered mice showed significant cognitive improvement in the T-maze, novel object recognition, and Morris water maze tests. Moreover, amyloidogenesis-related proteins, such as β-secretase and γ-secretase, were detected and their protein levels decreased after treatment with CT. Our study shows that CT attenuates cognitive dysfunction by improving learning and memory capability and regulating Aβ-related proteins in Aβ -injected mice. These findings suggest that CT might be a candidate for functional food on cognitive improvement.
ISSN:2304-8158
2304-8158
DOI:10.3390/foods11020142