Atrial fibrillation is associated with increased risk of lethal ventricular arrhythmias

Atrial fibrillation (AF) is associated with various major adverse cardiac events such as ischemic stroke, heart failure, and increased overall mortality. However, its association with lethal ventricular arrhythmias such as ventricular tachycardia (VT), ventricular flutter (VFL), and ventricular fibr...

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Bibliographic Details
Published in:Scientific reports 2021-09, Vol.11 (1), p.18111-18111, Article 18111
Main Authors: Kim, Yun Gi, Choi, Yun Young, Han, Kyung-Do, Min, Kyongjin, Choi, Ha Young, Shim, Jaemin, Choi, Jong-Il, Kim, Young-Hoon
Format: Article
Language:English
Subjects:
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Arrhythmia
Atrial Fibrillation - complications
Atrial Fibrillation - diagnosis
Atrial Fibrillation - epidemiology
Atrial Fibrillation - etiology
Biomarkers
Cardiac arrhythmia
Congestive heart failure
Databases, Factual
Disease Susceptibility
Electrocardiography
Fibrillation
Heart Function Tests
Humanities and Social Sciences
Humans
Ischemia
Kaplan-Meier Estimate
multidisciplinary
Population studies
Prognosis
Republic of Korea - epidemiology
Risk Assessment
Risk Factors
Science
Science (multidisciplinary)
Tachycardia
Ventricle
Ventricular Fibrillation - diagnosis
Ventricular Fibrillation - epidemiology
Ventricular Fibrillation - etiology
Ventricular Fibrillation - mortality
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Summary:Atrial fibrillation (AF) is associated with various major adverse cardiac events such as ischemic stroke, heart failure, and increased overall mortality. However, its association with lethal ventricular arrhythmias such as ventricular tachycardia (VT), ventricular flutter (VFL), and ventricular fibrillation (VF) is controversial. We conducted this study to determine whether AF can increase the risk of VT, VFL, and VF. We utilized the Korean National Health Insurance Service database for this nationwide population-based study. This study enrolled people who underwent a nationwide health screen in 2009 for whom clinical follow-up data were available until December 2018. Primary outcome endpoint was the occurrence of VT, VFL, or VF in people who were and were not diagnosed with new-onset AF in 2009. We analyzed a total of 9,751,705 people. In 2009, 12,689 people were diagnosed with new-onset AF (AF group). The incidence (events per 1000 person-years of follow-up) of VT, VFL, and VF was 2.472 and 0.282 in the AF and non-AF groups, respectively. After adjustment for covariates, new-onset AF was associated with 4.6-fold increased risk (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-97335-y