Music-performance regulates microRNAs in professional musicians

Musical training and performance require precise integration of multisensory and motor centres of the human brain and can be regarded as an epigenetic modifier of brain functions. Numerous studies have identified structural and functional differences between the brains of musicians and non-musicians...

Full description

Saved in:
Bibliographic Details
Published in:PeerJ (San Francisco, CA) CA), 2019-03, Vol.7, p.e6660-e6660, Article e6660
Main Authors: Nair, Preethy Sasidharan, Kuusi, Tuire, Ahvenainen, Minna, Philips, Anju K, Järvelä, Irma
Format: Article
Language:English
Subjects:
AKT protein
Analysis
Apoptosis
Auditory perception
Auditory plasticity
Axonogenesis
Binomial distribution
Bioinformatics
Brain
Brain research
Cell activation
Cell differentiation
Cell survival
Classical music
Cognition
Cognitive ability
Communication
Cyclic AMP response element-binding protein
Dopamine
Epigenetic inheritance
Ethics
Foxp2 protein
Gene expression
Gene regulation
Genes
Genetic regulation
Genetics
Genomes
Genomics
Hair
Learning
Memory
MicroRNA
MicroRNAs
miRNA
Music-performance
Musical instruments
Musical performances
Musicians
Musicians & conductors
Nervous system
Neurons
Neurophysiology
Neuroplasticity
Neuroscience
Neurosciences
Peripheral blood
Phenols (Class of compounds)
Phosphorylation
PTEN protein
Quality
Sensory integration
Sequencing
Signal transduction
Statistical analysis
Structure-function relationships
Training
Transcription
Zebra finch
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Musical training and performance require precise integration of multisensory and motor centres of the human brain and can be regarded as an epigenetic modifier of brain functions. Numerous studies have identified structural and functional differences between the brains of musicians and non-musicians and superior cognitive functions in musicians. Recently, music-listening and performance has also been shown to affect the regulation of several genes, many of which were identified in songbird singing. MicroRNAs affect gene regulation and studying their expression may give new insights into the epigenetic effect of music. Here, we studied the effect of 2 hours of classical music-performance on the peripheral blood microRNA expressions in professional musicians with respect to a control activity without music for the same duration. As detecting transcriptomic changes in the functional human brain remains a challenge for geneticists, we used peripheral blood to study music-performance induced microRNA changes and interpreted the results in terms of potential effects on brain function, based on the current knowledge about the microRNA function in blood and brain. We identified significant (FDR
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.6660