Vitamin D Receptor Expression and its Clinical Significance in Papillary Thyroid Cancer

Objective: This study aimed to evaluate the association between vitamin D receptor (an essential component in the vitamin D signaling pathway) and serum vitamin D as well as its clinical significance in papillary thyroid cancer. Methods: This prospective cohort study comprised patients with thyroid...

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Published in:Technology in cancer research & treatment 2022-04, Vol.21, p.15330338221089933-15330338221089933
Main Authors: Kim, Min Jhi, Kim, Daham, Koo, Ja Seung, Lee, Ju Hee, Nam, Kee-Hyun
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Clinical significance
Cyclin-dependent kinase inhibitor p21
Gene expression
Genomes
GTP-binding protein
Humans
Original
Papillary thyroid cancer
Patients
Prospective Studies
Protein expression
Proteins
Receptors, Calcitriol - genetics
Signal transduction
Thyroid cancer
Thyroid Cancer, Papillary - genetics
Thyroid Neoplasms - pathology
Vitamin D
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Summary:Objective: This study aimed to evaluate the association between vitamin D receptor (an essential component in the vitamin D signaling pathway) and serum vitamin D as well as its clinical significance in papillary thyroid cancer. Methods: This prospective cohort study comprised patients with thyroid tumors who visited our hospital, from 2017 to 2018. The level of vitamin D receptor expression from thyroid tissue was measured in patients with thyroid tumor and evaluated for correlation with serum vitamin D levels and clinicopathologic characteristics of papillary thyroid cancer. Data from 501 patients with papillary thyroid cancer from The Cancer Genome Atlas database were analyzed. Results: Increased vitamin D receptor protein and mRNA expression were observed in papillary thyroid cancer compared to those in normal and benign tissues. Lower vitamin D receptor protein expression was associated with high TNM stage papillary thyroid cancer and low p21 protein expression. Lower relative vitamin D receptor mRNA expression in papillary thyroid cancer was associated with low serum 25-hydroxyvitamin D level. The Cancer Genome Atlas database showed a positive correlation among mRNA expression of vitamin D receptor, CYP24A1, and p21. Conclusions: An association between decreased vitamin D receptor protein expression and advanced stage papillary thyroid cancer, and a correlation between low vitamin D receptor mRNA expression with low serum 25-hydroxyvitamin D level was observed. Low vitamin D receptor expression in papillary thyroid cancer was shown to positively correlate with low serum vitamin D level and disease aggressiveness.
ISSN:1533-0346
1533-0338
DOI:10.1177/15330338221089933