Vitamin D Receptor Expression and its Clinical Significance in Papillary Thyroid Cancer

Objective: This study aimed to evaluate the association between vitamin D receptor (an essential component in the vitamin D signaling pathway) and serum vitamin D as well as its clinical significance in papillary thyroid cancer. Methods: This prospective cohort study comprised patients with thyroid...

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Published in:Technology in cancer research & treatment 2022-04, Vol.21, p.15330338221089933-15330338221089933
Main Authors: Kim, Min Jhi, Kim, Daham, Koo, Ja Seung, Lee, Ju Hee, Nam, Kee-Hyun
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Clinical significance
Cyclin-dependent kinase inhibitor p21
Gene expression
Genomes
GTP-binding protein
Humans
Original
Papillary thyroid cancer
Patients
Prospective Studies
Protein expression
Proteins
Receptors, Calcitriol - genetics
Signal transduction
Thyroid cancer
Thyroid Cancer, Papillary - genetics
Thyroid Neoplasms - pathology
Vitamin D
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creator Kim, Min Jhi
Kim, Daham
Koo, Ja Seung
Lee, Ju Hee
Nam, Kee-Hyun
description Objective: This study aimed to evaluate the association between vitamin D receptor (an essential component in the vitamin D signaling pathway) and serum vitamin D as well as its clinical significance in papillary thyroid cancer. Methods: This prospective cohort study comprised patients with thyroid tumors who visited our hospital, from 2017 to 2018. The level of vitamin D receptor expression from thyroid tissue was measured in patients with thyroid tumor and evaluated for correlation with serum vitamin D levels and clinicopathologic characteristics of papillary thyroid cancer. Data from 501 patients with papillary thyroid cancer from The Cancer Genome Atlas database were analyzed. Results: Increased vitamin D receptor protein and mRNA expression were observed in papillary thyroid cancer compared to those in normal and benign tissues. Lower vitamin D receptor protein expression was associated with high TNM stage papillary thyroid cancer and low p21 protein expression. Lower relative vitamin D receptor mRNA expression in papillary thyroid cancer was associated with low serum 25-hydroxyvitamin D level. The Cancer Genome Atlas database showed a positive correlation among mRNA expression of vitamin D receptor, CYP24A1, and p21. Conclusions: An association between decreased vitamin D receptor protein expression and advanced stage papillary thyroid cancer, and a correlation between low vitamin D receptor mRNA expression with low serum 25-hydroxyvitamin D level was observed. Low vitamin D receptor expression in papillary thyroid cancer was shown to positively correlate with low serum vitamin D level and disease aggressiveness.
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Methods: This prospective cohort study comprised patients with thyroid tumors who visited our hospital, from 2017 to 2018. The level of vitamin D receptor expression from thyroid tissue was measured in patients with thyroid tumor and evaluated for correlation with serum vitamin D levels and clinicopathologic characteristics of papillary thyroid cancer. Data from 501 patients with papillary thyroid cancer from The Cancer Genome Atlas database were analyzed. Results: Increased vitamin D receptor protein and mRNA expression were observed in papillary thyroid cancer compared to those in normal and benign tissues. Lower vitamin D receptor protein expression was associated with high TNM stage papillary thyroid cancer and low p21 protein expression. Lower relative vitamin D receptor mRNA expression in papillary thyroid cancer was associated with low serum 25-hydroxyvitamin D level. The Cancer Genome Atlas database showed a positive correlation among mRNA expression of vitamin D receptor, CYP24A1, and p21. Conclusions: An association between decreased vitamin D receptor protein expression and advanced stage papillary thyroid cancer, and a correlation between low vitamin D receptor mRNA expression with low serum 25-hydroxyvitamin D level was observed. Low vitamin D receptor expression in papillary thyroid cancer was shown to positively correlate with low serum vitamin D level and disease aggressiveness.</description><identifier>ISSN: 1533-0346</identifier><identifier>EISSN: 1533-0338</identifier><identifier>DOI: 10.1177/15330338221089933</identifier><identifier>PMID: 35379049</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>25-Hydroxyvitamin D ; Clinical significance ; Cyclin-dependent kinase inhibitor p21 ; Gene expression ; Genomes ; GTP-binding protein ; Humans ; Original ; Papillary thyroid cancer ; Patients ; Prospective Studies ; Protein expression ; Proteins ; Receptors, Calcitriol - genetics ; Signal transduction ; Thyroid cancer ; Thyroid Cancer, Papillary - genetics ; Thyroid Neoplasms - pathology ; Vitamin D</subject><ispartof>Technology in cancer research &amp; treatment, 2022-04, Vol.21, p.15330338221089933-15330338221089933</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022. 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Methods: This prospective cohort study comprised patients with thyroid tumors who visited our hospital, from 2017 to 2018. The level of vitamin D receptor expression from thyroid tissue was measured in patients with thyroid tumor and evaluated for correlation with serum vitamin D levels and clinicopathologic characteristics of papillary thyroid cancer. Data from 501 patients with papillary thyroid cancer from The Cancer Genome Atlas database were analyzed. Results: Increased vitamin D receptor protein and mRNA expression were observed in papillary thyroid cancer compared to those in normal and benign tissues. Lower vitamin D receptor protein expression was associated with high TNM stage papillary thyroid cancer and low p21 protein expression. Lower relative vitamin D receptor mRNA expression in papillary thyroid cancer was associated with low serum 25-hydroxyvitamin D level. The Cancer Genome Atlas database showed a positive correlation among mRNA expression of vitamin D receptor, CYP24A1, and p21. Conclusions: An association between decreased vitamin D receptor protein expression and advanced stage papillary thyroid cancer, and a correlation between low vitamin D receptor mRNA expression with low serum 25-hydroxyvitamin D level was observed. 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treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Min Jhi</au><au>Kim, Daham</au><au>Koo, Ja Seung</au><au>Lee, Ju Hee</au><au>Nam, Kee-Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D Receptor Expression and its Clinical Significance in Papillary Thyroid Cancer</atitle><jtitle>Technology in cancer research &amp; treatment</jtitle><addtitle>Technol Cancer Res Treat</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>21</volume><spage>15330338221089933</spage><epage>15330338221089933</epage><pages>15330338221089933-15330338221089933</pages><issn>1533-0346</issn><eissn>1533-0338</eissn><abstract>Objective: This study aimed to evaluate the association between vitamin D receptor (an essential component in the vitamin D signaling pathway) and serum vitamin D as well as its clinical significance in papillary thyroid cancer. Methods: This prospective cohort study comprised patients with thyroid tumors who visited our hospital, from 2017 to 2018. The level of vitamin D receptor expression from thyroid tissue was measured in patients with thyroid tumor and evaluated for correlation with serum vitamin D levels and clinicopathologic characteristics of papillary thyroid cancer. Data from 501 patients with papillary thyroid cancer from The Cancer Genome Atlas database were analyzed. Results: Increased vitamin D receptor protein and mRNA expression were observed in papillary thyroid cancer compared to those in normal and benign tissues. Lower vitamin D receptor protein expression was associated with high TNM stage papillary thyroid cancer and low p21 protein expression. Lower relative vitamin D receptor mRNA expression in papillary thyroid cancer was associated with low serum 25-hydroxyvitamin D level. The Cancer Genome Atlas database showed a positive correlation among mRNA expression of vitamin D receptor, CYP24A1, and p21. Conclusions: An association between decreased vitamin D receptor protein expression and advanced stage papillary thyroid cancer, and a correlation between low vitamin D receptor mRNA expression with low serum 25-hydroxyvitamin D level was observed. Low vitamin D receptor expression in papillary thyroid cancer was shown to positively correlate with low serum vitamin D level and disease aggressiveness.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>35379049</pmid><doi>10.1177/15330338221089933</doi><orcidid>https://orcid.org/0000-0002-7791-2994</orcidid><oa>free_for_read</oa></addata></record>
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source SAGE Open Access; Publicly Available Content Database; PubMed Central
subjects 25-Hydroxyvitamin D
Clinical significance
Cyclin-dependent kinase inhibitor p21
Gene expression
Genomes
GTP-binding protein
Humans
Original
Papillary thyroid cancer
Patients
Prospective Studies
Protein expression
Proteins
Receptors, Calcitriol - genetics
Signal transduction
Thyroid cancer
Thyroid Cancer, Papillary - genetics
Thyroid Neoplasms - pathology
Vitamin D
title Vitamin D Receptor Expression and its Clinical Significance in Papillary Thyroid Cancer
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