The need for area under the curve measurements in the field of ganciclovir therapeutic drug monitoring in children: a case report

Ganciclovir pharmacokinetics is characterized by a high variability in drug exposure. Usually, monitoring of ganciclovir exposure is performed by measuring trough concentration. However, due to the specificity of pediatric pharmacokinetics, trough concentration measurements may not be a relevant sur...

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Bibliographic Details
Published in:BMC infectious diseases 2021-11, Vol.21 (1), p.1-1143, Article 1143
Main Authors: Duval, Xavier, Lemaitre, Florian, Pertuisel, Sophie, Probert, Jamie, Gandemer, Virginie, Verdier, Marie-Clémence, Tron, Camille
Format: Article
Language:English
Subjects:
Antiviral drugs
Antiviral therapy
Biomarkers
Case Report
Case reports
Children
Clinical medicine
Creatinine
Cytomegalovirus
Cytomegalovirus (CMV)
Cytomegalovirus infections
Diagnosis
Diseases
Dosage
Dosage and administration
Drug dosages
Drug therapy
Exposure
Ganciclovir
Hematological diseases
Hematopoietic stem cell transplantation
Hematopoietic stem cells
Infections
Intravenous administration
Life Sciences
Monitoring
Patient outcomes
Patient safety
Patients
Pediatrics
Pharmacodynamics
Pharmacokinetics
Pharmacology
Plasma
Stem cell transplantation
Stem cells
Telemedicine
Therapeutic drug monitoring
Transplantation
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Description
Summary:Ganciclovir pharmacokinetics is characterized by a high variability in drug exposure. Usually, monitoring of ganciclovir exposure is performed by measuring trough concentration. However, due to the specificity of pediatric pharmacokinetics, trough concentration measurements may not be a relevant surrogate of ganciclovir exposure. Area under the curve of concentration (AUC) may be a more appropriate biomarker. This case report highlights that monitoring ganciclovir exposure based on AUC should be performed to tailor drug dosage in order to improve treatment efficacy and safety in pediatric patients.
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-021-06828-8