Predictive Factors of Canine Malignant Hepatic Diseases with Multifocal Hepatic Lesions Using Clinicopathology, Ultrasonography, and Hepatobiliary Ultrasound Scores

• Published in: Animals (Basel) 2024-10, Vol.14 (19), p.2910
• Main Authors: Phosri, Aphinan, Chantawong, Pinkarn, Thitaram, Niyada, Pringproa, Kidsadagon, Thongtharb, Atigan
• Format: Article
• Language: English
• Subjects: Abdomen; Blood; clinicopathology; Dogs; Hematology; Hyperplasia; Leukocytes; Liver cancer; Liver diseases; multifocal hepatic lesions; Multivariate analysis; Tumors; Ultrasonic imaging; ultrasound hepatobiliary score; Variables; Veterinary medicine
• ISSN: 2076-2615; 2076-2615
• DOI: 10.3390/ani14192910

Multifocal hepatic lesions in dogs arise from various benign and malignant liver diseases. Diagnosing these lesions is challenging because clinical signs, hematological data, and serum biochemistry are not definitive indicators. Ultrasound is utilized as a diagnostic imaging tool to evaluate liver parenchyma and detect hepatic lesions. This study aims to investigate the predictive factors that differentiate between benign and malignant multifocal hepatic lesions by examining ultrasound characteristics, blood tests, and serum biochemistry. In total, 43 dogs with multifocal hepatic lesions were included in this study. All dogs were classified into benign hepatic diseases ( = 32) and malignant haptic diseases ( = 11). For all dogs, their liver characteristics, lesion characteristics, and hepatobiliary ultrasound score by ultrasound were evaluated and we collected individual clinicopathological data for analysis. The findings of the univariate analysis revealed significant differences in four hematological and blood chemical parameters (hematocrit, white blood cell count, aspartate transaminase (AST), and alkaline phosphatase (ALP)) and six ultrasonographic parameters (liver parenchymal echogenicity, lesion homogeneity, lesion echogenicity, maximum lesion dimension, average lesion dimension, and hepatobiliary ultrasound score). Using multivariate analysis, only two parameters, hepatobiliary ultrasound score and lesion homogeneity, showed significant differences ( -value < 0.001 and -value = 0.011, respectively). Additionally, these parameters demonstrated high accuracy in predicting malignant multifocal liver lesions, with accuracy rates of 97.67% and 93.02%, respectively. Therefore, the hepatobiliary ultrasound score and lesion homogeneity are considered effective parameters for screening malignant multifocal liver lesions in dogs.