Late HIV diagnosis is a major risk factor for intensive care unit admission in HIV-positive patients: a single centre observational cohort study

HIV positive patients are at risk of infectious and non-infectious complications that may necessitate intensive care unit (ICU) admission. While the characteristics of patients requiring ICU admission have been described previously, these studies did not include information on the denominator popula...

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Bibliographic Details
Published in:BMC infectious diseases 2013-01, Vol.13 (1), p.23-23, Article 23
Main Authors: Shrosbree, Julia, Campbell, Lucy J, Ibrahim, Fowzia, Hopkins, Phillip, Vizcaychipi, Marcela, Strachan, Stephanie, Post, Frank A
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Admission and discharge
Adult
AIDS
Analysis
Antiretroviral therapy
Antiviral agents
Care and treatment
cART
Cohort Studies
Confidence intervals
Delayed Diagnosis
Diagnosis
Disease
Emergency medical care
Female
Highly active antiretroviral therapy
HIV
HIV (Viruses)
HIV infection
HIV Infections - diagnosis
HIV Infections - epidemiology
HIV patients
HIV Seropositivity - diagnosis
HIV Seropositivity - epidemiology
Hospitalization
Hospitals
Human immunodeficiency virus
Humans
ICU
Immunodeficiency
Incidence
Infections
Intensive care
Intensive Care Units
Late
London - epidemiology
Male
Middle Aged
Mortality
Population
Risk Factors
Statistics
Studies
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Summary:HIV positive patients are at risk of infectious and non-infectious complications that may necessitate intensive care unit (ICU) admission. While the characteristics of patients requiring ICU admission have been described previously, these studies did not include information on the denominator population from which these cases arose. We conducted an observational cohort study of ICU admissions among 2751 HIV positive patients attending King's College Hospital, South London, UK. Poisson regression models were used to identify factors associated with ICU admission. The overall incidence rate of ICU admission was 1.0 [95% CI 0.8, 1.2] per 100 person-years of follow up, and particularly high early (during the first 3 months) following HIV diagnosis (12.4 [8.7, 17.3] per 100 person-years compared to 0.37 [0.27, 0.50] per 100 person-years thereafter; incidence rate ratio 33.5 [23.4, 48.1], p 
ISSN:1471-2334
1471-2334
DOI:10.1186/1471-2334-13-23