Study of the efficacy and safety of various pharmacotherapy regimens for atypical depression in the framework of bipolar affective disorder, recurrent depressive disorder, psychogenic depression

IntroductionTo improve the effectiveness of treatment for atypical depression, it is necessary to revise the accumulated experience, taking into account new knowledge and drugs.ObjectivesComparative study of the efficacy and safety of therapy for atypical depression (AtD) in the structure of bipolar...

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Bibliographic Details
Published in:European psychiatry 2022-06, Vol.65 (S1), p.S565-S566
Main Authors: Verbitskaya, M., Tyuvina, N., Tyulpin, Y.
Format: Article
Language:English
Subjects:
Abstract
Antidepressants
Antipsychotics
atypical depression
Bipolar Affective Disorder
Bipolar disorder
E-Poster Viewing
Mental depression
psychogenic depression
Psychotropic drugs
recurrent depressive disorder
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Summary:IntroductionTo improve the effectiveness of treatment for atypical depression, it is necessary to revise the accumulated experience, taking into account new knowledge and drugs.ObjectivesComparative study of the efficacy and safety of therapy for atypical depression (AtD) in the structure of bipolar affective disorder (BAD), recurrent depressive disorder (RDR) and psychogenic depression (PD).MethodsClinical and clinical follow-up methods examined 77 patients with AtD, of which 35 - with bipolar disorder, 18 - with RDR and 24 - with PD. Patients in all three groups received monotherapy with an antidepressant or a mood stabilizer, or a combination of antidepressant and antipsychotic, antidepressant and mood stabilizer, mood stabilizer and antipsychotic, as well as a combination of antidepressant, antipsychotic and mood stabilizer.ResultsAgomelatine was the most frequently used (27.3%) and effective in reducing MADRS in all groups both in monotherapy and in combination with other drugs. Also in the PD group, escitalopram and vortioxetine were highly effective. Of the antipsychotics, when combined with antidepressants, sulpiride was found to be the most effective. When comparing the tolerance of antidepressants in all groups showed the best results (by the CGI scale), agomelatine and venlafaxine, in the BAR group is also vortioxetine.ConclusionsThe best strategy for effective and safe treatment of atypical depression is the use of modern antidepressant, which does not increase the symptoms of the atypical spectrum and, if necessary, can be supplemented with some antipsychotics.DisclosureNo significant relationships.
ISSN:0924-9338
1778-3585
DOI:10.1192/j.eurpsy.2022.1448