MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis

The process of metabolic re-programing is linked to the activation of oncogenes and/or suppression of tumour suppressor genes, which are regulated by microRNAs (miRNAs). The interplay between oncogenic transformation-driven metabolic re-programming and modulation of aberrant miRNAs further establish...

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Bibliographic Details
Published in:International journal of molecular sciences 2016-05, Vol.17 (5), p.754-754
Main Authors: Tomasetti, Marco, Amati, Monica, Santarelli, Lory, Neuzil, Jiri
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Carcinogenesis - genetics
Carcinogenesis - metabolism
Gene Expression Regulation, Neoplastic
Humans
Metabolic Networks and Pathways
metabolic reprogramming
MicroRNAs - genetics
miR-126 and cancer-stroma environment
miRNA regulating signaling pathways
miRNAs
Oncogene Proteins - genetics
Oncogene Proteins - metabolism
Review
Tumor Microenvironment
tumorigenesis
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Summary:The process of metabolic re-programing is linked to the activation of oncogenes and/or suppression of tumour suppressor genes, which are regulated by microRNAs (miRNAs). The interplay between oncogenic transformation-driven metabolic re-programming and modulation of aberrant miRNAs further established their critical role in the initiation, promotion and progression of cancer by creating a tumorigenesis-prone microenvironment, thus orchestrating processes of evasion to apoptosis, angiogenesis and invasion/migration, as well metastasis. Given the involvement of miRNAs in tumour development and their global deregulation, they may be perceived as biomarkers in cancer of therapeutic relevance.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms17050754