Cerebral hemodynamic plasticity related to potential compensatory self-recirculation network in Moyamoya disease: an observational study

• Published in: Scientific reports 2024-10, Vol.14 (1), p.26059-9, Article 26059
• Main Authors: Cao, Lei, Yuan, Xiaoli, Dong, Yang, Wang, Zeming, Guo, Mengguo, Li, Dongpeng, Wang, Hao, Zhu, Lingyun, Yang, Bo, Li, Hongwei
• Format: Article
• Language: English
• Subjects: 631/136/2441; 631/378/1689; 631/378/2607; 692/308/409; 692/420/256; 692/499; 692/698/1688/64; 692/700/459; 692/700/565; Adult; Anastomosis; Blood flow; Cerebral infarction; Cerebral Revascularization - methods; Cerebrovascular Circulation - physiology; Female; FLOW800; Hemodynamics; Humanities and Social Sciences; Humans; Male; Microvasculature; Middle Aged; Moyamoya disease; Moyamoya Disease - physiopathology; Moyamoya Disease - surgery; multidisciplinary; Observational studies; Perioperative complication; Prospective Studies; Science; Science (multidisciplinary); Self-recirculation network
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-75058-0

Moyamoya disease (MMD) suffers from impaired cerebrovascular hemodynamics and high perioperative complications occurrence. This study aims to propose and evaluate the relationship between intraoperative hemodynamics and perioperative complications, and propose a potential compensatory self-recirculation network in MMD. We prospectively enrolled 63 MMD patients undergone combined revascularization, and patients were divided into decreased and increased group according to decreased and increased microvascular transit time (MVTT), respectively. Mean age of all patients was 45.9 ± 9.4 years. The post-bypass hyperperfusion syndrome occurrence was significantly higher in the decreased MVTT group, and the cerebral infarction occurrence was significantly higher in the increased MVTT group. For the hemodynamics of the recipient artery around anastomosis, the parameters of distal site demonstrated a significant higher intensity and shorter time in the decreased MVTT group, while the parameters of the proximal site demonstrated a significant higher intensity and shorter time in the increased MVTT group. Pre-bypass and post-bypass collision of blood flow in artery and vein were firstly observed and illustrated. Intraoperative hemodynamics showed close relationship with perioperative complications. The blood flow of MMD seems to develop a unique compensatory self-recirculation system and contribute to the clinical complications, providing a new insight to the clinical management the pathology of the disease.