Case report: Metastatic ovarian mucinous carcinoma to the breast: diagnostic challenges and pitfalls

Metastases to the breast from extramammary sources are extremely rare, with the ovary, primarily high-grade serous carcinoma, being the most common origin. We report a case of breast metastases from advanced stage ovarian mucinous carcinoma in a 48-year-old female- a case hitherto unreported in the...

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Bibliographic Details
Published in:Frontiers in oncology 2024-03, Vol.14, p.1364011
Main Authors: Laokulrath, Natthawadee, Lim, Siew Kuan, Lim, Hwee Yong, Gudi, Mihir, Tan, Puay Hoon
Format: Article
Language:English
Subjects:
basement membrane
in-situ-like structures
metastatic to the breast
nipple metastasis
Oncology
ovarian mucinous carcinoma
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Summary:Metastases to the breast from extramammary sources are extremely rare, with the ovary, primarily high-grade serous carcinoma, being the most common origin. We report a case of breast metastases from advanced stage ovarian mucinous carcinoma in a 48-year-old female- a case hitherto unreported in the literature. The case is noteworthy for its atypical presentation marked by an areolar rash, clinically suggestive of Paget disease of the nipple. This unique clinical scenario, coupled with histopathological examination revealing -like carcinoma component, posed a diagnostic challenge in discerning the tumour origin. We emphasize the need for heightened awareness among pathologists to avoid misdiagnosing metastatic carcinomas as primary breast tumours, a potential pitfall with significant clinical implications.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2024.1364011