The emerging roles of SUMOylation in the tumor microenvironment and therapeutic implications

Tumor initiation, progression, and response to therapies depend to a great extent on interactions between malignant cells and the tumor microenvironment (TME), which denotes the cancerous/non-cancerous cells, cytokines, chemokines, and various other factors around tumors. Cancer cells as well as str...

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Bibliographic Details
Published in:Experimental hematology & oncology 2023-07, Vol.12 (1), p.58-58, Article 58
Main Authors: Gu, Yunru, Fang, Yuan, Wu, Xi, Xu, Tingting, Hu, Tong, Xu, Yangyue, Ma, Pei, Wang, Qiang, Shu, Yongqian
Format: Article
Language:English
Subjects:
Angiogenesis
Breast cancer
Cancer
Carcinogens
Cell cycle
Cell growth
Chemotherapy
Colorectal cancer
Cytokines
Development and progression
Enzymes
Esophageal cancer
Genetic transcription
Growth factors
Health aspects
Hypoxia
Inflammation
Kinases
Liver cancer
Lung cancer
Metabolism
Metastasis
Phosphorylation
Physiological aspects
Post-translational modification
Proteins
Review
SUMOylation
Tumor microenvironment
Tumorigenesis
Tumors
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Summary:Tumor initiation, progression, and response to therapies depend to a great extent on interactions between malignant cells and the tumor microenvironment (TME), which denotes the cancerous/non-cancerous cells, cytokines, chemokines, and various other factors around tumors. Cancer cells as well as stroma cells can not only obtain adaption to the TME but also sculpt their microenvironment through a series of signaling pathways. The post-translational modification (PTM) of eukaryotic cells by small ubiquitin-related modifier (SUMO) proteins is now recognized as a key flexible pathway. Proteins involved in tumorigenesis guiding several biological processes including chromatin organization, DNA repair, transcription, protein trafficking, and signal conduction rely on SUMOylation. The purpose of this review is to explore the role that SUMOylation plays in the TME formation and reprogramming, emphasize the importance of targeting SUMOylation to intervene in the TME and discuss the potential of SUMOylation inhibitors (SUMOi) in ameliorating tumor prognosis.
ISSN:2162-3619
2162-3619
DOI:10.1186/s40164-023-00420-3