Fecal Microbiota Transplantation in Inflammatory Bowel Disease

Inflammatory bowel diseases represent a complex array of diseases of incompletely known etiology that led to gastrointestinal tract chronic inflammation. In inflammatory bowel disease, a promising method of treatment is represented by fecal microbiota transplantation (FMT), FMT has shown its increas...

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Bibliographic Details
Published in:Biomedicines 2023-03, Vol.11 (4), p.1016
Main Authors: Boicean, Adrian, Birlutiu, Victoria, Ichim, Cristian, Anderco, Paula, Birsan, Sabrina
Format: Article
Language:English
Subjects:
Abdomen
Antibiotics
Bacteria
Constipation
Crohn's disease
Diarrhea
E coli
fecal microbiota transplantation
Fecal microflora
Feces
Gastrointestinal tract
Immune response
Immune system
Infections
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Intestine
Irritable bowel syndrome
Metabolism
Microbiota
microbiota transplantation
Pathogens
Patients
Physiological aspects
Review
Severe acute respiratory syndrome coronavirus 2
Transplantation
Transplants & implants
Ulcerative colitis
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Summary:Inflammatory bowel diseases represent a complex array of diseases of incompletely known etiology that led to gastrointestinal tract chronic inflammation. In inflammatory bowel disease, a promising method of treatment is represented by fecal microbiota transplantation (FMT), FMT has shown its increasing effectiveness and safety in recent years for recurrent CDI; moreover, it showed real clinical benefits in treating SARS-CoV-2 and CDI co-infection. Crohn's disease and ulcerative colitis are characterized by immune dysregulation, resulting in digestive tract damage caused by immune responses. Most current therapeutic strategies are associated with high costs and many adverse effects by directly targeting the immune response, so modifying the microbial environment by FMT offers an alternative approach that could indirectly influence the host's immune system in a safe way. Studies outline the endoscopic and clinical improvements in UC and CD in FMT patients versus control groups. This review outlines the multiple benefits of FMT in the case of IBD by improving patients unbalanced gut, therefore improving endoscopic and clinical symptomatology. We aim to emphasize the clinical importance and benefits of FMT in order to prevent flares or complications of IBD and to highlight that further validation is needed for establishing a clinical protocol for FMT in IBD.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11041016