Anti-apoptotic proteins in the autophagic world: an update on functions of XIAP, Survivin, and BRUCE

X-linked inhibitor of apoptosis protein (XIAP), survivin, and BRUCE are members of the inhibitor-of-apoptosis protein (IAP) family known for their inhibitory effects on caspase activity and dysregulation of these molecules has widely been shown to cause embryonic defects and to promote tumorigenesis...

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Bibliographic Details
Published in:Journal of biomedical science 2020-02, Vol.27 (1), p.31-31, Article 31
Main Authors: Cheung, Chun Hei Antonio, Chang, Yung-Chieh, Lin, Tzu-Yu, Cheng, Siao Muk, Leung, Euphemia
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
BRUCE
Cancer
Cancer cells
Caspase
Cell adhesion & migration
Cell cycle
Clinical trials
Deoxyribonucleic acid
DIABLO protein
Diseases
DNA
Drug development
Embryos
IAP
IAP protein
Inhibitors
Kinases
Medical research
Mitochondria
Phagocytosis
Proteins
Review
Side effects
Smac
Survival
Survivin
Tumorigenesis
Tumors
XIAP protein
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Summary:X-linked inhibitor of apoptosis protein (XIAP), survivin, and BRUCE are members of the inhibitor-of-apoptosis protein (IAP) family known for their inhibitory effects on caspase activity and dysregulation of these molecules has widely been shown to cause embryonic defects and to promote tumorigenesis in human. Besides the anti-apoptotic functions, recent discoveries have revealed that XIAP, survivin, and BRUCE also exhibit regulatory functions for autophagy in cells. As the role of autophagy in human diseases has already been discussed extensively in different reviews; in this review, we will discuss the emerging autophagic role of XIAP, survivin, and BRUCE in cancer cells. We also provide an update on the anti-apoptotic functions and the roles in maintaining DNA integrity of these molecules. Second mitochondria-derived activator of caspases (Smac) is a pro-apoptotic protein and IAPs are the molecular targets of various Smac mimetics currently under clinical trials. Better understanding on the functions of XIAP, survivin, and BRUCE can enable us to predict possible side effects of these drugs and to design a more "patient-specific" clinical trial for Smac mimetics in the future.
ISSN:1423-0127
1021-7770
1423-0127
DOI:10.1186/s12929-020-0627-5