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Vegetal-Derived Bioactive Compounds as Multidrug Resistance Modulators in Colorectal Cancer
Colorectal cancer is one of the leading causes of morbidity and mortality today. Knowledge of its pathogenesis has made it possible to advance the development of different therapeutic strategies. However, the appearance of drug resistance constitutes one of the main causes of treatment failure. Bioa...
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| Published in: | Applied sciences 2023-02, Vol.13 (4), p.2667 |
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| Main Authors: | , , , , , , , |
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| creator | Quiñonero, Francisco Mesas, Cristina Peña, Mercedes Cabeza, Laura Perazzoli, Gloria Melguizo, Consolación Ortiz, Raul Prados, Jose |
| description | Colorectal cancer is one of the leading causes of morbidity and mortality today. Knowledge of its pathogenesis has made it possible to advance the development of different therapeutic strategies. However, the appearance of drug resistance constitutes one of the main causes of treatment failure. Bioactive compounds of vegetable origin are being studied as a new strategy to improve antitumor treatment, due to their ability to regulate the pathways involved in the development of carcinogenesis or processes that are decisive in its evolution, including multidrug resistance. In vitro and in vivo studies of these substances in combination with cytotoxic drugs have shown that they reduce resistance and increase therapeutic efficacy. The objective of this review is to summarize the knowledge that is described in the scientific literature on the antitumor and chemo-sensitizing capacity of vegetable-derived biomolecules such as polyphenols, flavonoids, and terpenes. These compounds may hold a promising future in improving the treatment of colorectal cancer. |
| doi_str_mv | 10.3390/app13042667 |
| format | article |
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Knowledge of its pathogenesis has made it possible to advance the development of different therapeutic strategies. However, the appearance of drug resistance constitutes one of the main causes of treatment failure. Bioactive compounds of vegetable origin are being studied as a new strategy to improve antitumor treatment, due to their ability to regulate the pathways involved in the development of carcinogenesis or processes that are decisive in its evolution, including multidrug resistance. In vitro and in vivo studies of these substances in combination with cytotoxic drugs have shown that they reduce resistance and increase therapeutic efficacy. The objective of this review is to summarize the knowledge that is described in the scientific literature on the antitumor and chemo-sensitizing capacity of vegetable-derived biomolecules such as polyphenols, flavonoids, and terpenes. 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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| subjects | Apoptosis Bioactive compounds Bioflavonoids Biological activity Biomolecules Cancer Cancer therapies Carcinogenesis Carcinogens Cell growth Chemotherapy Colorectal cancer Colorectal carcinoma Cytotoxicity Development and progression Drug resistance Drug resistance in microorganisms Flavones Flavonoids Health aspects In vivo methods and tests Morbidity Multidrug resistance Polyphenols resistance mechanisms Vegetables Vincristine |
| title | Vegetal-Derived Bioactive Compounds as Multidrug Resistance Modulators in Colorectal Cancer |
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