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Genetic and immune identification and functional analysis of TRPM8 as a potential biomarker for pancreatic adenocarcinoma proliferation
Background Pancreatic adenocarcinoma (PAAD), a member of highly lethal malignant tumors, has a poor outcome and extremely poor prognosis. The transient receptor potential (TRP) superfamily, a group of nonselective cation channels, is capable of influencing cellular functions by regulating calcium ho...
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| Published in: | Cancer reports 2024-06, Vol.7 (6), p.e2108-n/a |
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| creator | Qiao, Sen Wu, Fengming Wang, Hongmei |
| description | Background
Pancreatic adenocarcinoma (PAAD), a member of highly lethal malignant tumors, has a poor outcome and extremely poor prognosis. The transient receptor potential (TRP) superfamily, a group of nonselective cation channels, is capable of influencing cellular functions by regulating calcium homeostasis. In addition, it has been shown that TRP channels can also affect various cellular phenotypes by regulating gene transcription levels and are involved in the development of a variety of malignant tumors.
Aims
In order to find new therapeutic targets and biomarkers to improve the clinical prognosis of pancreatic cancer, we performed genetic and immunological characterization of TRP channels in PAAD, as well as related functional and prognostic analyses.
Methods and Results
We investigated the expression, genetic alterations, methylation levels, and immune infiltration levels of TRP channels in PAAD, and further also analyzed the function of TRP channels in PAAD and their prognostic value for PAAD patients. Our results suggest that TRPM8 may contribute to tumor proliferation by controlling the PI3K‐AKT–mTOR signaling pathway in PAAD.
Conclusion
After careful evaluation of the accumulated data, we concluded that TRPM8 has potential as a prognostic indicator and prospective therapeutic target in PAAD. |
| doi_str_mv | 10.1002/cnr2.2108 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_c317823c36ce4085bf38334ff97df96b</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_c317823c36ce4085bf38334ff97df96b</doaj_id><sourcerecordid>3065275655</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3728-6b24638990d743adea08bf8297e87b214bc16754a9ddd59c9096f326060ab683</originalsourceid><addsrcrecordid>eNp1kstu1TAQQCMEolXpgh9AXsLitn4kfqwQuiqlUnmountr4tjFJbGDnYDuF_DbOLmlahes7PEcnxnLU1WvCT4jGNNzExI9owTLZ9UxbQTbSFbL54_2R9VpzncYYyI5o4q9rI6YlExIUR9Xfy5tsJM3CEKH_DDMwSLf2TB55w1MPoY14-ZglgD6EkK_zz6j6NDu5ttniSAjQGOcllsFaH0cIP2wCbmY0AjBJAtrieKNBpLxoRBoTLH3zqa1yqvqhYM-29P79aTafbzYbT9trr9eXm0_XG8ME1RueEtrzqRSuBM1K0LAsnWSKmGlaCmpW0O4aGpQXdc1yiisuGOUY46h5ZKdVFcHbRfhTo_Jl073OoLX60FMtxpS6bW32jAiJGWGcWNrLJvWMclY7ZwSnVO8La73B9c4t4PtTHl-gv6J9Gkm-O_6Nv7ShJAGY4mL4e29IcWfs82THnw2tu8h2DhnzTBvqGh40xT03QE1KeacrHuoQ7Be5kAvc6CXOSjsm8eNPZD_fr0A5wfgt-_t_v8mvf1yQ1flXxNYvs0</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3065275655</pqid></control><display><type>article</type><title>Genetic and immune identification and functional analysis of TRPM8 as a potential biomarker for pancreatic adenocarcinoma proliferation</title><source>Wiley</source><source>Wiley Online Library Open Access</source><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Qiao, Sen ; Wu, Fengming ; Wang, Hongmei</creator><creatorcontrib>Qiao, Sen ; Wu, Fengming ; Wang, Hongmei</creatorcontrib><description>Background
Pancreatic adenocarcinoma (PAAD), a member of highly lethal malignant tumors, has a poor outcome and extremely poor prognosis. The transient receptor potential (TRP) superfamily, a group of nonselective cation channels, is capable of influencing cellular functions by regulating calcium homeostasis. In addition, it has been shown that TRP channels can also affect various cellular phenotypes by regulating gene transcription levels and are involved in the development of a variety of malignant tumors.
Aims
In order to find new therapeutic targets and biomarkers to improve the clinical prognosis of pancreatic cancer, we performed genetic and immunological characterization of TRP channels in PAAD, as well as related functional and prognostic analyses.
Methods and Results
We investigated the expression, genetic alterations, methylation levels, and immune infiltration levels of TRP channels in PAAD, and further also analyzed the function of TRP channels in PAAD and their prognostic value for PAAD patients. Our results suggest that TRPM8 may contribute to tumor proliferation by controlling the PI3K‐AKT–mTOR signaling pathway in PAAD.
Conclusion
After careful evaluation of the accumulated data, we concluded that TRPM8 has potential as a prognostic indicator and prospective therapeutic target in PAAD.</description><identifier>ISSN: 2573-8348</identifier><identifier>EISSN: 2573-8348</identifier><identifier>DOI: 10.1002/cnr2.2108</identifier><identifier>PMID: 38837874</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - immunology ; Adenocarcinoma - pathology ; Aged ; bioinformatic ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Cell Line, Tumor ; Cell Proliferation - genetics ; DNA Methylation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Original ; pancreatic adenocarcinoma ; Pancreatic Neoplasms - genetics ; Pancreatic Neoplasms - immunology ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Phosphatidylinositol 3-Kinases - metabolism ; Prognosis ; prognostic markers ; Signal Transduction ; TOR Serine-Threonine Kinases - metabolism ; transient receptor potential channel ; TRPM Cation Channels - genetics ; TRPM8</subject><ispartof>Cancer reports, 2024-06, Vol.7 (6), p.e2108-n/a</ispartof><rights>2024 The Author(s). published by Wiley Periodicals LLC.</rights><rights>2024 The Author(s). Cancer Reports published by Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3728-6b24638990d743adea08bf8297e87b214bc16754a9ddd59c9096f326060ab683</cites><orcidid>0000-0002-6975-9467</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11150080/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11150080/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11562,27924,27925,37013,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38837874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qiao, Sen</creatorcontrib><creatorcontrib>Wu, Fengming</creatorcontrib><creatorcontrib>Wang, Hongmei</creatorcontrib><title>Genetic and immune identification and functional analysis of TRPM8 as a potential biomarker for pancreatic adenocarcinoma proliferation</title><title>Cancer reports</title><addtitle>Cancer Rep (Hoboken)</addtitle><description>Background
Pancreatic adenocarcinoma (PAAD), a member of highly lethal malignant tumors, has a poor outcome and extremely poor prognosis. The transient receptor potential (TRP) superfamily, a group of nonselective cation channels, is capable of influencing cellular functions by regulating calcium homeostasis. In addition, it has been shown that TRP channels can also affect various cellular phenotypes by regulating gene transcription levels and are involved in the development of a variety of malignant tumors.
Aims
In order to find new therapeutic targets and biomarkers to improve the clinical prognosis of pancreatic cancer, we performed genetic and immunological characterization of TRP channels in PAAD, as well as related functional and prognostic analyses.
Methods and Results
We investigated the expression, genetic alterations, methylation levels, and immune infiltration levels of TRP channels in PAAD, and further also analyzed the function of TRP channels in PAAD and their prognostic value for PAAD patients. Our results suggest that TRPM8 may contribute to tumor proliferation by controlling the PI3K‐AKT–mTOR signaling pathway in PAAD.
Conclusion
After careful evaluation of the accumulated data, we concluded that TRPM8 has potential as a prognostic indicator and prospective therapeutic target in PAAD.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - immunology</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>bioinformatic</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - genetics</subject><subject>DNA Methylation</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>pancreatic adenocarcinoma</subject><subject>Pancreatic Neoplasms - genetics</subject><subject>Pancreatic Neoplasms - immunology</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Prognosis</subject><subject>prognostic markers</subject><subject>Signal Transduction</subject><subject>TOR Serine-Threonine Kinases - metabolism</subject><subject>transient receptor potential channel</subject><subject>TRPM Cation Channels - genetics</subject><subject>TRPM8</subject><issn>2573-8348</issn><issn>2573-8348</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>DOA</sourceid><recordid>eNp1kstu1TAQQCMEolXpgh9AXsLitn4kfqwQuiqlUnmountr4tjFJbGDnYDuF_DbOLmlahes7PEcnxnLU1WvCT4jGNNzExI9owTLZ9UxbQTbSFbL54_2R9VpzncYYyI5o4q9rI6YlExIUR9Xfy5tsJM3CEKH_DDMwSLf2TB55w1MPoY14-ZglgD6EkK_zz6j6NDu5ttniSAjQGOcllsFaH0cIP2wCbmY0AjBJAtrieKNBpLxoRBoTLH3zqa1yqvqhYM-29P79aTafbzYbT9trr9eXm0_XG8ME1RueEtrzqRSuBM1K0LAsnWSKmGlaCmpW0O4aGpQXdc1yiisuGOUY46h5ZKdVFcHbRfhTo_Jl073OoLX60FMtxpS6bW32jAiJGWGcWNrLJvWMclY7ZwSnVO8La73B9c4t4PtTHl-gv6J9Gkm-O_6Nv7ShJAGY4mL4e29IcWfs82THnw2tu8h2DhnzTBvqGh40xT03QE1KeacrHuoQ7Be5kAvc6CXOSjsm8eNPZD_fr0A5wfgt-_t_v8mvf1yQ1flXxNYvs0</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Qiao, Sen</creator><creator>Wu, Fengming</creator><creator>Wang, Hongmei</creator><general>John Wiley and Sons Inc</general><general>Wiley</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6975-9467</orcidid></search><sort><creationdate>202406</creationdate><title>Genetic and immune identification and functional analysis of TRPM8 as a potential biomarker for pancreatic adenocarcinoma proliferation</title><author>Qiao, Sen ; Wu, Fengming ; Wang, Hongmei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3728-6b24638990d743adea08bf8297e87b214bc16754a9ddd59c9096f326060ab683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - immunology</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>bioinformatic</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - genetics</topic><topic>DNA Methylation</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>pancreatic adenocarcinoma</topic><topic>Pancreatic Neoplasms - genetics</topic><topic>Pancreatic Neoplasms - immunology</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Prognosis</topic><topic>prognostic markers</topic><topic>Signal Transduction</topic><topic>TOR Serine-Threonine Kinases - metabolism</topic><topic>transient receptor potential channel</topic><topic>TRPM Cation Channels - genetics</topic><topic>TRPM8</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qiao, Sen</creatorcontrib><creatorcontrib>Wu, Fengming</creatorcontrib><creatorcontrib>Wang, Hongmei</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Cancer reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qiao, Sen</au><au>Wu, Fengming</au><au>Wang, Hongmei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic and immune identification and functional analysis of TRPM8 as a potential biomarker for pancreatic adenocarcinoma proliferation</atitle><jtitle>Cancer reports</jtitle><addtitle>Cancer Rep (Hoboken)</addtitle><date>2024-06</date><risdate>2024</risdate><volume>7</volume><issue>6</issue><spage>e2108</spage><epage>n/a</epage><pages>e2108-n/a</pages><issn>2573-8348</issn><eissn>2573-8348</eissn><abstract>Background
Pancreatic adenocarcinoma (PAAD), a member of highly lethal malignant tumors, has a poor outcome and extremely poor prognosis. The transient receptor potential (TRP) superfamily, a group of nonselective cation channels, is capable of influencing cellular functions by regulating calcium homeostasis. In addition, it has been shown that TRP channels can also affect various cellular phenotypes by regulating gene transcription levels and are involved in the development of a variety of malignant tumors.
Aims
In order to find new therapeutic targets and biomarkers to improve the clinical prognosis of pancreatic cancer, we performed genetic and immunological characterization of TRP channels in PAAD, as well as related functional and prognostic analyses.
Methods and Results
We investigated the expression, genetic alterations, methylation levels, and immune infiltration levels of TRP channels in PAAD, and further also analyzed the function of TRP channels in PAAD and their prognostic value for PAAD patients. Our results suggest that TRPM8 may contribute to tumor proliferation by controlling the PI3K‐AKT–mTOR signaling pathway in PAAD.
Conclusion
After careful evaluation of the accumulated data, we concluded that TRPM8 has potential as a prognostic indicator and prospective therapeutic target in PAAD.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>38837874</pmid><doi>10.1002/cnr2.2108</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0002-6975-9467</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - genetics Adenocarcinoma - immunology Adenocarcinoma - pathology Aged bioinformatic Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cell Line, Tumor Cell Proliferation - genetics DNA Methylation Female Gene Expression Regulation, Neoplastic Humans Male Middle Aged Original pancreatic adenocarcinoma Pancreatic Neoplasms - genetics Pancreatic Neoplasms - immunology Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Phosphatidylinositol 3-Kinases - metabolism Prognosis prognostic markers Signal Transduction TOR Serine-Threonine Kinases - metabolism transient receptor potential channel TRPM Cation Channels - genetics TRPM8 |
| title | Genetic and immune identification and functional analysis of TRPM8 as a potential biomarker for pancreatic adenocarcinoma proliferation |
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