Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma

Histone lysine lactylation (Kla) plays a vital role in the tumorigenesis of hepatocellular carcinoma (HCC). Hence, we focused on Kla-specific genes to select novel therapeutic targets. Differentially expressed Kla-specific genes (DEKlaGs) were identified from TCGA with the cut-off criteria |log 2 (F...

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Bibliographic Details
Published in:Scientific reports 2023-10, Vol.13 (1), p.18642-18642, Article 18642
Main Authors: Wu, Qinjuan, Li, Xin, Long, Menghong, Xie, Xianfeng, Liu, Qing
Format: Article
Language:English
Subjects:
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Biomarkers
Chemoresistance
Chemotherapy
Drug resistance
Gene set enrichment analysis
Hepatocellular carcinoma
Histones
Humanities and Social Sciences
Immunotherapy
Liver cancer
Lysine
MAP kinase
Medical prognosis
Metastases
Microenvironments
multidisciplinary
Natural killer cells
Prognosis
Science
Science (multidisciplinary)
Therapeutic applications
Therapeutic targets
TOR protein
Tumorigenesis
Wnt protein
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Summary:Histone lysine lactylation (Kla) plays a vital role in the tumorigenesis of hepatocellular carcinoma (HCC). Hence, we focused on Kla-specific genes to select novel therapeutic targets. Differentially expressed Kla-specific genes (DEKlaGs) were identified from TCGA with the cut-off criteria |log 2 (FlodChange (FC))| > 2, p-value 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-46057-4