Intermittent alternating magnetic fields diminish metal-associated biofilm in vivo

Prosthetic joint infection (PJI) is a complication of arthroplasty that results in significant morbidity. The presence of biofilm makes treatment difficult, and removal of the prosthesis is frequently required. We have developed a non-invasive approach for biofilm eradication from metal implants usi...

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Bibliographic Details
Published in:Scientific reports 2023-12, Vol.13 (1), p.22456-22456, Article 22456
Main Authors: Shaikh, Sumbul, Lapin, Norman A., Prasad, Bibin, Sturge, Carolyn R., Pybus, Christine, Pifer, Reed, Wang, Qi, Evers, Bret M., Chopra, Rajiv, Greenberg, David E.
Format: Article
Language:English
Subjects:
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Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Biofilms
Humanities and Social Sciences
Humans
Joint diseases
Magnetic Fields
Metals
Morbidity
multidisciplinary
Prosthesis-Related Infections - drug therapy
Science
Science (multidisciplinary)
Staphylococcus aureus
Transplants & implants
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Summary:Prosthetic joint infection (PJI) is a complication of arthroplasty that results in significant morbidity. The presence of biofilm makes treatment difficult, and removal of the prosthesis is frequently required. We have developed a non-invasive approach for biofilm eradication from metal implants using intermittent alternating magnetic fields (iAMF) to generate targeted heating at the implant surface. The goal of this study was to determine whether iAMF demonstrated efficacy in an in vivo implant biofilm infection model. iAMF combined with antibiotics led to enhanced reduction of biofilm on metallic implants in vivo compared to antibiotics or untreated control. iAMF-antibiotic combinations resulted in a > 1 − log further reduction in biofilm burden compared to antibiotics or iAMF alone. This combination effect was seen in both S. aureus and P. aeruginosa and seen with multiple antibiotics used to treat infections with these pathogens. In addition, efficacy was temperature dependent with increasing temperatures resulting in a greater reduction of biofilm. Tissue damage was limited (
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-49660-7