Clinical features and virological confirmation of perinatal dengue infection in Jambi, Indonesia: A case report

•Vertical transmission of dengue in mother and baby was observed in Jambi, Indonesia.•Clinical features were described, with mother experiencing severe dengue.•Dengue virus RNAs were extracted from sera of both mother and baby.•NGS sequencing revealed identical DENV genomes in mother and baby.•Both...

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Bibliographic Details
Published in:International journal of infectious diseases 2019-09, Vol.86, p.197-200
Main Authors: Haryanto, Sotianingsih, Yohan, Benediktus, Santoso, Marsha Sinditia, Hayati, Rahma F., Denis, Dionisius, Udjung, Gorga I.V.W., Herlambang, Kendarsari, R. Indah, Trimarsanto, Hidayat, Sasmono, R. Tedjo
Format: Article
Language:English
Subjects:
Dengue
Neonate
Next-generation sequencing
Perinatal
Pregnancy
Vertical transmission
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Summary:•Vertical transmission of dengue in mother and baby was observed in Jambi, Indonesia.•Clinical features were described, with mother experiencing severe dengue.•Dengue virus RNAs were extracted from sera of both mother and baby.•NGS sequencing revealed identical DENV genomes in mother and baby.•Both mother and neonate possess anti-dengue antibodies measured using PRNT. The hyper-endemicity of dengue in Indonesia poses a significant threat of dengue virus (DENV) vertical transmission during pregnancy. A 29-year-old female at 38 weeks of pregnancy presented to hospital with acute fever and later confirmed with DENV infection. Due to signs of fetal distress, the neonate was delivered by emergency caesarean section. The mother developed a dengue critical phase post-caesarean with excessive bleeding and required blood transfusion. During the 6th day of life, the neonate was diagnosed and later confirmed with dengue. Next-generation sequencing of DENV RNA isolated directly from sera of both mother and neonate revealed identical DENV-2 whole-genome sequences. Plaque reduction neutralization test (PRNT) detected anti-dengue antibodies in both mother and neonate. Altogether, our data confirmed the occurrence of vertical transmission. Dengue vertical transmission during pregnancy may lead to severe manifestation, hence early diagnosis, close monitoring, and prompt intervention are critical.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2019.07.019