Low maternal vitamin B12 status is associated with lower cord blood HDL cholesterol in white Caucasians living in the UK

Studies in South Asian population show that low maternal vitamin B12 associates with insulin resistance and small for gestational age in the offspring. Low vitamin B12 status is attributed to vegetarianism in these populations. It is not known whether low B12 status is associated with metabolic risk...

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Bibliographic Details
Published in:Nutrients 2015-04, Vol.7 (4), p.2401-2414
Main Authors: Adaikalakoteswari, Antonysunil, Vatish, Manu, Lawson, Alexander, Wood, Catherine, Sivakumar, Kavitha, McTernan, Philip G, Webster, Craig, Anderson, Neil, Yajnik, Chittaranjan S, Tripathi, Gyanendra, Saravanan, Ponnusamy
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - metabolism
Body Mass Index
Body Weight
Cardiovascular disease
Cholesterol
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cross-Sectional Studies
Diabetes
Diet, Vegetarian
Electronic mail systems
European Continental Ancestry Group
Female
Fetal Blood - chemistry
Folic Acid - blood
Gestational Age
High density lipoprotein
Homocysteine
Homocysteine - metabolism
Hospitals
Humans
Insulin - blood
Insulin Resistance
lipids
maternal
Maternal Nutritional Physiological Phenomena
Metabolic disorders
metabolic risk
Nutrients
Nutritional Status
Obesity
offspring
Pregnancy
Research ethics
Risk Factors
Triglycerides
Triglycerides - blood
United Kingdom
Vegetarianism
Vitamin B
Vitamin B 12 - blood
vitamin B12
White people
Womens health
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Summary:Studies in South Asian population show that low maternal vitamin B12 associates with insulin resistance and small for gestational age in the offspring. Low vitamin B12 status is attributed to vegetarianism in these populations. It is not known whether low B12 status is associated with metabolic risk of the offspring in whites, where the childhood metabolic disorders are increasing rapidly. Here, we studied whether maternal B12 levels associate with metabolic risk of the offspring at birth. This is a cross-sectional study of 91 mother-infant pairs (n = 182), of white Caucasian origin living in the UK. Blood samples were collected from white pregnant women at delivery and their newborns (cord blood). Serum vitamin B12, folate, homocysteine as well as the relevant metabolic risk factors were measured. The prevalence of low serum vitamin B12 (
ISSN:2072-6643
2072-6643
DOI:10.3390/nu7042401