Continued Complexity of Mutations in Omicron Sublineages

The latest SARS-CoV-2 variant of concern (VOC), Omicron (B.1.1.529), has diversified into more than 300 sublineages. With an expanding number of newly emerging sublineages, the mutation profile is also becoming complicated. There exist mutually exclusive and revertant mutations in different sublinea...

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Bibliographic Details
Published in:Biomedicines 2022-10, Vol.10 (10), p.2593
Main Authors: Spratt, Austin N, Kannan, Saathvik R, Sharma, Kalicharan, Sachdev, Shrikesh, Kandasamy, Shree L, Sönnerborg, Anders, Lorson, Christian L, Singh, Kamal
Format: Article
Language:English
Subjects:
Application programming interface
Coronaviruses
Enzymes
Flexibility
Genetic aspects
Medicin och hälsovetenskap
molecular dynamics
Monoclonal antibodies
mutant modeling
Mutation
Omicron sublineages
Proteins
revertant mutations
Severe acute respiratory syndrome coronavirus 2
Simulation
structural flexibility
variant of concern (VOC)
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Summary:The latest SARS-CoV-2 variant of concern (VOC), Omicron (B.1.1.529), has diversified into more than 300 sublineages. With an expanding number of newly emerging sublineages, the mutation profile is also becoming complicated. There exist mutually exclusive and revertant mutations in different sublineages. Omicron sublineages share some common mutations with previous VOCs (Alpha, Beta, Gamma, and Delta), indicating an evolutionary relationship between these VOCs. A diverse mutation profile at the spike-antibody interface, flexibility of the regions harboring mutations, mutation types, and coexisting mutations suggest that SARS-CoV-2's evolution is far from over.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10102593