Regulatory role of the programmed cell death 1 signaling pathway in sepsis induced immunosuppression

Sepsis is a multiple organ dysfunction syndrome caused by the host's immune response to infection, with extremely high incidence and mortality. Immunosuppression is an essential pathophysiological alteration that influences the clinical treatment and prognosis of sepsis. Recent studies have sug...

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Bibliographic Details
Published in:Frontiers in immunology 2023-05, Vol.14, p.1183542-1183542
Main Authors: Zhong, Shubai, Yin, Yuanqin
Format: Article
Language:English
Subjects:
Immunology
immunomodulation
immunosuppression
immunotherapy
programmed cell death 1
sepsis
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Summary:Sepsis is a multiple organ dysfunction syndrome caused by the host's immune response to infection, with extremely high incidence and mortality. Immunosuppression is an essential pathophysiological alteration that influences the clinical treatment and prognosis of sepsis. Recent studies have suggested that the programmed cell death 1 signaling pathway is involved in the formation of immunosuppression in sepsis. In this review, we systematically present the mechanisms of immune dysregulation in sepsis and elucidate the expression and regulatory effects of the programmed cell death 1 signaling pathway on immune cells associated with sepsis. We then specify current research developments and prospects for the application of the programmed cell death 1 signaling pathway in immunomodulatory therapy for sepsis. Several open questions and future research are discussed at the end.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1183542